Technology Process of NO2-(Et)ACHA-(D)Phe-OtBu
There total 1 articles about NO2-(Et)ACHA-(D)Phe-OtBu which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 24h;
DOI:10.1021/ja907233q
- Guidance literature:
-
With
hydrogenchloride;
In
1,4-dioxane;
at 20 ℃;
for 3h;
DOI:10.1021/ja907233q
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrogenchloride / 1,4-dioxane / 3 h / 20 °C
2: N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 48 h / 20 °C
3: hydrogen / Raney nickel / methanol / 16 h / 2068.65 Torr
4: N-ethyl-N,N-diisopropylamine / dichloromethane / 5 h / 20 °C
With
hydrogenchloride; hydrogen; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;
Raney nickel;
In
1,4-dioxane; methanol; dichloromethane;
