2α-methyl-1α,25-dihydroxyvitamin D3-26,23-lactam-N-(3,5-diethoxybenzyl)

Base Information

• Chemical Name: 2α-methyl-1α,25-dihydroxyvitamin D3-26,23-lactam-N-(3,5-diethoxybenzyl)
• CAS No.: 1226764-42-6
• Molecular Formula: C₃₉H₅₇NO₆
• Molecular Weight: 635.885
• Mol file: 1226764-42-6.mol

Synonyms:2α-methyl-1α,25-dihydroxyvitamin D3-26,23-lactam-N-(3,5-diethoxybenzyl)

Chemical Property of 2α-methyl-1α,25-dihydroxyvitamin D3-26,23-lactam-N-(3,5-diethoxybenzyl)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2α-methyl-1α,25-dihydroxyvitamin D3-26,23-lactam-N-(3,5-diethoxybenzyl)

There total 7 articles about 2α-methyl-1α,25-dihydroxyvitamin D3-26,23-lactam-N-(3,5-diethoxybenzyl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C54H93NO6Si3 (1226764-38-0) → 2α-methyl-1α,25-dihydroxyvitamin D3-26,23-lactam-N-(3,5-diethoxybenzyl) (1226764-43-7) + 2α-methyl-1α,25-dihydroxyvitamin D3-26,23-lactam-N-(3,5-diethoxybenzyl) (1226764-41-5) + 2α-methyl-1α,25-dihydroxyvitamin D3-26,23-lactam-N-(3,5-diethoxybenzyl) (1226764-40-4) + 2α-methyl-1α,25-dihydroxyvitamin D3-26,23-lactam-N-(3,5-diethoxybenzyl) (1226764-42-6)

Guidance literature:

With triethylamine tris(hydrogen fluoride); In tetrahydrofuran; at 40 ℃; for 50h;

Reference yield:

3,5-diethoxybenzaldehyde (120355-79-5) → 2α-methyl-1α,25-dihydroxyvitamin D3-26,23-lactam-N-(3,5-diethoxybenzyl) (1226764-43-7) + 2α-methyl-1α,25-dihydroxyvitamin D3-26,23-lactam-N-(3,5-diethoxybenzyl) (1226764-41-5) + 2α-methyl-1α,25-dihydroxyvitamin D3-26,23-lactam-N-(3,5-diethoxybenzyl) (1226764-40-4) + 2α-methyl-1α,25-dihydroxyvitamin D3-26,23-lactam-N-(3,5-diethoxybenzyl) (1226764-42-6)

Guidance literature:

Multi-step reaction with 7 steps

1: hydroxylamine hydrochloride; triethylamine / dichloromethane / 2 h / 20 °C

2: triethylamine / dichloromethane / 2 h / 20 °C / Inert atmosphere

3: toluene / 1.5 h / 90 °C / Inert atmosphere

4: water; molybdenum hexacarbonyl / acetonitrile / 3.5 h / 90 °C

5: dichloromethane / 1 h / 20 °C / Inert atmosphere

6: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 110 °C / Inert atmosphere

7: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 50 h / 40 °C

With hydroxylamine hydrochloride; water; triethylamine tris(hydrogen fluoride); triethylamine; molybdenum hexacarbonyl; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;

Reference yield:

C31H46BrNO5 → 2α-methyl-1α,25-dihydroxyvitamin D3-26,23-lactam-N-(3,5-diethoxybenzyl) (1226764-43-7) + 2α-methyl-1α,25-dihydroxyvitamin D3-26,23-lactam-N-(3,5-diethoxybenzyl) (1226764-41-5) + 2α-methyl-1α,25-dihydroxyvitamin D3-26,23-lactam-N-(3,5-diethoxybenzyl) (1226764-40-4) + 2α-methyl-1α,25-dihydroxyvitamin D3-26,23-lactam-N-(3,5-diethoxybenzyl) (1226764-42-6)

Guidance literature:

Multi-step reaction with 4 steps

1: water; molybdenum hexacarbonyl / acetonitrile / 3.5 h / 90 °C

2: dichloromethane / 1 h / 20 °C / Inert atmosphere

3: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 2 h / 110 °C / Inert atmosphere

4: triethylamine tris(hydrogen fluoride) / tetrahydrofuran / 50 h / 40 °C

With water; triethylamine tris(hydrogen fluoride); triethylamine; molybdenum hexacarbonyl; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; toluene; acetonitrile;

upstream raw materials:

3,5-diethoxybenzaldehyde

C₁₁H₁₅NO₃

C₅₄H₉₃NO₆Si₃

Refernces