cyclohexyl-[3,5-dibromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]amine

Base Information

Chemical Name:cyclohexyl-[3,5-dibromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]amine
CAS No.:1071137-68-2
Molecular Formula:C₁₉H₁₇Br₂ClN₄
Molecular Weight:496.632
Hs Code.:

Synonyms:cyclohexyl-[3,5-dibromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of cyclohexyl-[3,5-dibromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]amine

Chemical Property:

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Technology Process of cyclohexyl-[3,5-dibromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]amine

There total 12 articles about cyclohexyl-[3,5-dibromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1071137-22-8
[4-(1-chloro[2,6]naphthyridin-3-yl)pyridin-2-yl]cyclohexylamine

: 1071137-68-2
cyclohexyl-[3,5-dibromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]amine

Guidance literature:: With N-Bromosuccinimide; In N,N-dimethyl-formamide; for 18h;

Reference yield:

: 55-22-1
pyridine-4-carboxylic acid

: 1071137-68-2
cyclohexyl-[3,5-dibromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]amine

Guidance literature:: Multi-step reaction with 11 steps

1.1: triethylamine / dichloromethane / 0.92 h / 0 °C

1.2: 3.5 h / 0 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 1.67 h / -75 °C

2.2: -75 - 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 2 h / -78 °C

4.1: acetic acid / 100 °C

5.1: ammonia / ethanol; water / 20 °C

6.1: tetramethlyammonium chloride; trichlorophosphate / 36 h / 110 °C

7.1: 3 h / Heating / reflux

8.1: potassium tert-butylate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 100 °C

9.1: potassium tert-butylate; water / tert-butyl alcohol / 100 °C

10.1: tetramethlyammonium chloride; trichlorophosphate / 110 °C

11.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 18 h

With N-Bromosuccinimide; n-butyllithium; potassium tert-butylate; ammonia; water; tetramethlyammonium chloride; acetic acid; triethylamine; trichlorophosphate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;

Reference yield:

: 1003-73-2
3-picoline-N-oxide

: 1071137-68-2
cyclohexyl-[3,5-dibromo-4-(1-chloro-[2,6]naphthyridin-3-yl)pyridin-2-yl]amine

Guidance literature:: Multi-step reaction with 11 steps

1.1: dimethyl sulfate / 0 - 40 °C

1.2: 40 °C

2.1: sulfuric acid / dichloromethane / 8 h / 20 °C

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.5 h / -78 °C

3.2: 2 h / -78 °C

4.1: acetic acid / 100 °C

5.1: ammonia / ethanol; water / 20 °C

6.1: tetramethlyammonium chloride; trichlorophosphate / 36 h / 110 °C

7.1: 3 h / Heating / reflux

8.1: potassium tert-butylate / palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 100 °C

9.1: potassium tert-butylate; water / tert-butyl alcohol / 100 °C

10.1: tetramethlyammonium chloride; trichlorophosphate / 110 °C

11.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 18 h

With N-Bromosuccinimide; n-butyllithium; sulfuric acid; potassium tert-butylate; ammonia; water; tetramethlyammonium chloride; acetic acid; dimethyl sulfate; trichlorophosphate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; toluene; tert-butyl alcohol;