5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-[1,3,4]thiadiazol-2-ylamine

Base Information

• Chemical Name: 5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-[1,3,4]thiadiazol-2-ylamine
• CAS No.: 1155877-88-5
• Molecular Formula: C₁₆H₁₃ClFN₃OS
• Molecular Weight: 349.816

Synonyms:5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-[1,3,4]thiadiazol-2-ylamine

Chemical Property of 5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-[1,3,4]thiadiazol-2-ylamine

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Technology Process of 5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-[1,3,4]thiadiazol-2-ylamine

There total 1 articles about 5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-[1,3,4]thiadiazol-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-yl)-acetonitrile (1155877-87-4) + thiosemicarbazide (79-19-6) → 5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-[1,3,4]thiadiazol-2-ylamine (1155877-88-5)

Guidance literature:

With trifluoroacetic acid; at 60 ℃; for 6h; Product distribution / selectivity;

Reference yield: 67.0%

5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-[1,3,4]thiadiazol-2-ylamine (1155877-88-5) + Glycine ethyl ester isocyanate (2949-22-6) → {3-[5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-[1,3,4]thiadiazol-2-yl]-ureido}-acetic acid ethyl ester (1155876-88-2)

Guidance literature:

With pyridine; at 20 ℃; for 72h;

Reference yield: 36.0%

5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-[1,3,4]thiadiazol-2-ylamine (1155877-88-5) + isocyanatobutanoic acid ethyl ester (106508-62-7) → 4-{3-[5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-[1,3,4]thiadiazol-2-yl]-ureido}-butyric acid ethyl ester (1155877-35-2)

Guidance literature:

With pyridine; at 20 - 50 ℃; for 42h;

upstream raw materials:

(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-yl)-acetonitrile

thiosemicarbazide

Downstream raw materials:

4-{3-[5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-[1,3,4]thiadiazol-2-yl]-ureido}-butyric acid ethyl ester

{3-[5-(3'-Chloro-2-fluoro-6-methoxy-biphenyl-3-ylmethyl)-[1,3,4]thiadiazol-2-yl]-ureido}-acetic acid ethyl ester

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