(4R)-2-[(1'R,2'S)-1',2'-Methano-3'-(tert-butyldiphenylsilyloxy)propyl]-4-methoxycarbonyl-4,5-dihydrothiazole

Base Information

Chemical Name:(4R)-2-[(1'R,2'S)-1',2'-Methano-3'-(tert-butyldiphenylsilyloxy)propyl]-4-methoxycarbonyl-4,5-dihydrothiazole
CAS No.:251444-07-2
Molecular Formula:C₂₅H₃₁NO₃SSi
Molecular Weight:453.678
Hs Code.:

Synonyms:(4R)-2-[(1'R,2'S)-1',2'-Methano-3'-(tert-butyldiphenylsilyloxy)propyl]-4-methoxycarbonyl-4,5-dihydrothiazole

Suppliers and Price of (4R)-2-[(1'R,2'S)-1',2'-Methano-3'-(tert-butyldiphenylsilyloxy)propyl]-4-methoxycarbonyl-4,5-dihydrothiazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (4R)-2-[(1'R,2'S)-1',2'-Methano-3'-(tert-butyldiphenylsilyloxy)propyl]-4-methoxycarbonyl-4,5-dihydrothiazole

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (4R)-2-[(1'R,2'S)-1',2'-Methano-3'-(tert-butyldiphenylsilyloxy)propyl]-4-methoxycarbonyl-4,5-dihydrothiazole

There total 7 articles about (4R)-2-[(1'R,2'S)-1',2'-Methano-3'-(tert-butyldiphenylsilyloxy)propyl]-4-methoxycarbonyl-4,5-dihydrothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 251444-06-1
N-[(2'R,3'S)-4'-(tert-Butyldiphenylsilyloxy)-2',3'-methanobutanoyl]-(S)-cysteine methyl ester

: 251444-07-2
(4R)-2-[(1'R,2'S)-1',2'-Methano-3'-(tert-butyldiphenylsilyloxy)propyl]-4-methoxycarbonyl-4,5-dihydrothiazole

Guidance literature:: With titanium tetrachloride; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1039/a904378k

Reference yield:

: 154001-53-3
(1Z,4'S)-3-<(tert-Butyldiphenylsilyl)oxy>-1-(2',2'-dimethyl-1',3'-dioxolan-4'-yl)-1-propene

: 251444-07-2
(4R)-2-[(1'R,2'S)-1',2'-Methano-3'-(tert-butyldiphenylsilyloxy)propyl]-4-methoxycarbonyl-4,5-dihydrothiazole

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / Et₂Zn / hexane; CH₂Cl₂ / -23 - 0 °C

2: 100 percent / H₅IO₆ / diethyl ether / 10 h / 20 °C

3: 97 percent / KMnO₄; potassium hydrogen orthophosphate buffer; H₂O / 2-methyl-propan-2-ol / 0.08 h / pH 4.4

4: N-methylmorpholine / CH₂Cl₂ / 0.25 h / -10 °C

5: N-methylmorpholine / CH₂Cl₂ / 2 h / 20 °C

6: 91 percent / TiCl₄ / CH₂Cl₂ / 2 h / 0 °C

With 4-methyl-morpholine; potassium permanganate; potassium hydrogen orthophosphate buffer; water; diethylzinc; titanium tetrachloride; periodic acid; In diethyl ether; hexane; dichloromethane; tert-butyl alcohol; 1: Addition / 2: Oxidation / 3: Oxidation / 4: Substitution / 5: Acylation / 6: Cyclization;
DOI:10.1039/a904378k

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 251444-07-2
(4R)-2-[(1'R,2'S)-1',2'-Methano-3'-(tert-butyldiphenylsilyloxy)propyl]-4-methoxycarbonyl-4,5-dihydrothiazole

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / Et₃N; DMAP / CH₂Cl₂

2: 97 percent / Et₂Zn / hexane; CH₂Cl₂ / -23 - 0 °C

3: 100 percent / H₅IO₆ / diethyl ether / 10 h / 20 °C

4: 97 percent / KMnO₄; potassium hydrogen orthophosphate buffer; H₂O / 2-methyl-propan-2-ol / 0.08 h / pH 4.4

5: N-methylmorpholine / CH₂Cl₂ / 0.25 h / -10 °C

6: N-methylmorpholine / CH₂Cl₂ / 2 h / 20 °C

7: 91 percent / TiCl₄ / CH₂Cl₂ / 2 h / 0 °C

With 4-methyl-morpholine; dmap; potassium permanganate; potassium hydrogen orthophosphate buffer; water; diethylzinc; titanium tetrachloride; periodic acid; triethylamine; In diethyl ether; hexane; dichloromethane; tert-butyl alcohol; 1: Etherification / 2: Addition / 3: Oxidation / 4: Oxidation / 5: Substitution / 6: Acylation / 7: Cyclization;
DOI:10.1039/a904378k