(+)-{(1S,10R)-5-benzyloxy-1-(10-chloroethyl)-3-[(5-(2-N,N-dimethylaminoethoxy)-indol-2-yl)-carbonyl]-1,2-dihydro-3H-benz[e]indole}

Base Information

Chemical Name:(+)-{(1S,10R)-5-benzyloxy-1-(10-chloroethyl)-3-[(5-(2-N,N-dimethylaminoethoxy)-indol-2-yl)-carbonyl]-1,2-dihydro-3H-benz[e]indole}
CAS No.:945674-83-9
Molecular Formula:C₃₄H₃₄ClN₃O₃
Molecular Weight:568.115
Hs Code.:

Synonyms:(+)-{(1S,10R)-5-benzyloxy-1-(10-chloroethyl)-3-[(5-(2-N,N-dimethylaminoethoxy)-indol-2-yl)-carbonyl]-1,2-dihydro-3H-benz[e]indole}

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Chemical Property of (+)-{(1S,10R)-5-benzyloxy-1-(10-chloroethyl)-3-[(5-(2-N,N-dimethylaminoethoxy)-indol-2-yl)-carbonyl]-1,2-dihydro-3H-benz[e]indole}

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Technology Process of (+)-{(1S,10R)-5-benzyloxy-1-(10-chloroethyl)-3-[(5-(2-N,N-dimethylaminoethoxy)-indol-2-yl)-carbonyl]-1,2-dihydro-3H-benz[e]indole}

There total 2 articles about (+)-{(1S,10R)-5-benzyloxy-1-(10-chloroethyl)-3-[(5-(2-N,N-dimethylaminoethoxy)-indol-2-yl)-carbonyl]-1,2-dihydro-3H-benz[e]indole} which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-benzyloxy-1-(1-chloro-ethyl)-2,3-dihydro-1H-benzo[e]indole

: 5-<2-(dimethylamino)ethoxy>-1H-indole-2-carboxylic acid hydrochloride

: 945674-83-9
(+)-{(1S,10R)-5-benzyloxy-1-(10-chloroethyl)-3-[(5-(2-N,N-dimethylaminoethoxy)-indol-2-yl)-carbonyl]-1,2-dihydro-3H-benz[e]indole}

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 19h;
DOI:10.1002/anie.200600936

Reference yield:

: 916667-93-1
(+)-(1S,10R)-5-benzyloxy-3-(tert-butyloxycarbonyl)-1-(10-chloroethyl)-1,2-dihydro-3H-benz[e]indole

: 945674-83-9
(+)-{(1S,10R)-5-benzyloxy-1-(10-chloroethyl)-3-[(5-(2-N,N-dimethylaminoethoxy)-indol-2-yl)-carbonyl]-1,2-dihydro-3H-benz[e]indole}

Guidance literature:: Multi-step reaction with 2 steps

1: aq. HCl / ethyl acetate / 3.5 h / 20 °C

2: 196 mg / 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride / dimethylformamide / 19 h / 20 °C

With hydrogenchloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1002/chem.200700113