N-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(diethoxy-phosphoryl)-phenyl]-1-methyl-ethyl}-oxalamic acid tert-butyl ester

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Chemical Name:N-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(diethoxy-phosphoryl)-phenyl]-1-methyl-ethyl}-oxalamic acid tert-butyl ester
CAS No.:690254-54-7
Molecular Formula:C₄₄H₆₀N₅O₁₀P
Molecular Weight:849.962
Hs Code.:

<i>N</i>-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(diethoxy-phosphoryl)-phenyl]-1-methyl-ethyl}-oxalamic acid <i>tert</i>-butyl ester

Synonyms:N-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(diethoxy-phosphoryl)-phenyl]-1-methyl-ethyl}-oxalamic acid tert-butyl ester

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Chemical Property of N-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(diethoxy-phosphoryl)-phenyl]-1-methyl-ethyl}-oxalamic acid tert-butyl ester

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Technology Process of N-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(diethoxy-phosphoryl)-phenyl]-1-methyl-ethyl}-oxalamic acid tert-butyl ester

There total 6 articles about N-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(diethoxy-phosphoryl)-phenyl]-1-methyl-ethyl}-oxalamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 39061-59-1
t-butoxalyl chloride

: 690254-52-5
[4-((S)-2-tert-Butoxycarbonylamino-2-{1-[(S)-2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-propyl)-phenyl]-phosphonic acid diethyl ester

: 690254-54-7
N-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(diethoxy-phosphoryl)-phenyl]-1-methyl-ethyl}-oxalamic acid tert-butyl ester

Guidance literature:: [4-((S)-2-tert-Butoxycarbonylamino-2-{1-[(S)-2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-propyl)-phenyl]-phosphonic acid diethyl ester; With methoxybenzene; trifluoroacetic acid; at 20 ℃; for 2h;

t-butoxalyl chloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 0 - 50 ℃; Further stages.;
DOI:10.1016/j.tet.2004.02.005

Reference yield:

: 16004-15-2
1-bromomethyl-4-iodobenzene

: 690254-54-7
N-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(diethoxy-phosphoryl)-phenyl]-1-methyl-ethyl}-oxalamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: KHMDS / tetrahydrofuran; toluene / 0.08 h / -78 °C

1.2: 86 percent / tetrahydrofuran; toluene / 0.5 h / -78 °C

2.1: 74 percent / Et₃N; Pd(PPh₃)4 / toluene / 6 h / 90 °C

3.1: H₂ / Pd/C / tetrahydrofuran; ethanol

4.1: 1.92 g / Et₃N / dimethylformamide; H₂O / 96 h / 0 °C

5.1: tetramethylfluoroformamidinium hexafluorophosphate / dimethylformamide / 0.17 h / 20 °C

5.2: 71 percent / i-Pr₂EtN / dimethylformamide / 24 h / 50 °C

6.1: TFA; anisole / 2 h / 20 °C

6.2: 58 percent / i-Pr₂EtN / dimethylformamide / 0 - 50 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; potassium hexamethylsilazane; methoxybenzene; triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2004.02.005

Reference yield:

: 690254-40-1
(3S,5S,6R)-4-(benzyloxycarbonyl)-5,6-diphenyl-3-(4-iodo)benzyl-3-methyl-2,3,5,6-tetrahydro-4H-1,4-oxazin-2-one

: 690254-54-7
N-{1-{1-[2-carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-cyclohexylcarbamoyl}-2-[4-(diethoxy-phosphoryl)-phenyl]-1-methyl-ethyl}-oxalamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 74 percent / Et₃N; Pd(PPh₃)4 / toluene / 6 h / 90 °C

2.1: H₂ / Pd/C / tetrahydrofuran; ethanol

3.1: 1.92 g / Et₃N / dimethylformamide; H₂O / 96 h / 0 °C

4.1: tetramethylfluoroformamidinium hexafluorophosphate / dimethylformamide / 0.17 h / 20 °C

4.2: 71 percent / i-Pr₂EtN / dimethylformamide / 24 h / 50 °C

5.1: TFA; anisole / 2 h / 20 °C

5.2: 58 percent / i-Pr₂EtN / dimethylformamide / 0 - 50 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen; methoxybenzene; triethylamine; fluoro-N,N,N',N'-tetramethylformamidinium hexafluorophosphate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tet.2004.02.005