7-O-triethylsilyl-10-deacetoxy-11-hydro-12,13ene-13-deoxy-13-acetylamino baccatin III

Base Information

Chemical Name:7-O-triethylsilyl-10-deacetoxy-11-hydro-12,13ene-13-deoxy-13-acetylamino baccatin III
CAS No.:178329-34-5
Molecular Formula:C₃₇H₅₃NO₉Si
Molecular Weight:683.915
Hs Code.:

Synonyms:7-O-triethylsilyl-10-deacetoxy-11-hydro-12,13ene-13-deoxy-13-acetylamino baccatin III

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Chemical Property of 7-O-triethylsilyl-10-deacetoxy-11-hydro-12,13ene-13-deoxy-13-acetylamino baccatin III

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Technology Process of 7-O-triethylsilyl-10-deacetoxy-11-hydro-12,13ene-13-deoxy-13-acetylamino baccatin III

There total 4 articles about 7-O-triethylsilyl-10-deacetoxy-11-hydro-12,13ene-13-deoxy-13-acetylamino baccatin III which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 7-O-triethylsilyl-10-deacetoxy-13-deoxy-13-acetylimino baccatin III

: 178329-34-5
7-O-triethylsilyl-10-deacetoxy-11-hydro-12,13ene-13-deoxy-13-acetylamino baccatin III

Guidance literature:: With NaBHrCN; toluene-4-sulfonic acid; In tetrahydrofuran; at 0 ℃; for 3h;

Reference yield: 57.0%

: 108-24-7
acetic anhydride

: 178329-27-6
7-O-triethylsilyl-10-deacetoxy-13-deoxy-13-imino baccatin III

: 178329-34-5
7-O-triethylsilyl-10-deacetoxy-11-hydro-12,13ene-13-deoxy-13-acetylamino baccatin III

Guidance literature:: With sodium cyanoborohydride; In tetrahydrofuran; at 22 ℃; for 0.666667h;

Reference yield:

: 7-O-triethylsilyl-13-deoxy-13-oximino baccatin III

: 178329-34-5
7-O-triethylsilyl-10-deacetoxy-11-hydro-12,13ene-13-deoxy-13-acetylamino baccatin III

Guidance literature:: Multi-step reaction with 2 steps

1: 57 percent / hydrazine hydrate; Raney-nickel / H₂O / 3 h / 22 °C

2: 57 percent / NaBH₃CN / tetrahydrofuran / 0.67 h / 22 °C

With nickel; sodium cyanoborohydride; hydrazine hydrate; In tetrahydrofuran; water; 1: Reduction / 2: Reduction;