6-Methoxypicolinamide

Base Information

• Chemical Name: 6-Methoxypicolinamide
• CAS No.: 98276-69-8
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.153
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID60603273
• Wikidata: Q82500614
• Mol file: 98276-69-8.mol

Synonyms:6-Methoxypicolinamide;98276-69-8;6-Methoxypyridine-2-carboxamide;6-Methoxy-pyridine-2-carboxylic acid amide;SCHEMBL2304053;DTXSID60603273;FYSOQIKOUXQYSU-UHFFFAOYSA-N;YDA27669;MFCD08062921;AKOS006284482;AB43417;TS-02023;CS-0150320;C77359;A845833;6-Methoxy-pyridine-2-carboxylic acid amide, AldrichCPR;6-Methoxypyridine-2-carboxylic acid amide

Chemical Property of 6-Methoxypicolinamide

Chemical Property:

• Vapor Pressure: 0.00288mmHg at 25°C
• Melting Point: 108-109掳C
• Refractive Index: 1.55
• Boiling Point: 285°Cat760mmHg
• Flash Point: 126.2°C
• PSA: 65.21000
• Density: 1.213g/cm³
• LogP: 0.88940
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 0.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 152.058577502
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

98%Min ^*data from raw suppliers

6-Methoxypyridine-2-carboxamide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC(=N1)C(=O)N

Technology Process of 6-Methoxypicolinamide

There total 3 articles about 6-Methoxypicolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-methoxypyridine (1628-89-3) + formamide (77287-34-4,77287-35-5,60100-09-6) → 6-methoxypyridine-2-carboxamide (98276-69-8)

Guidance literature:

With dipotassium peroxodisulfate; oxygen; sodium formate; silver nitrate; In water; at 80 ℃; for 4h; regioselective reaction; Schlenk technique;

DOI:10.1055/s-0035-1561975

Reference yield: 81.0%

→ (6-methoxy-pyridin-2-yl)-methanol (63071-12-5) + 6-methoxypyridine-2-carboxamide (98276-69-8)

Guidance literature:

Reference yield:

→ 6-methoxypyridine-2-carboxamide (98276-69-8)

Guidance literature:

/BRN= 471850/ (m.p. = 86 - 88grad), MeOH , Na ; Erhitzen auf 100 - 110grad;

upstream raw materials:

2-methoxypyridine

formamide

Refernces

• 1、 -. "Method for synthesizing pyridine primary amides by direct catalytic oxidation process". Paragraph 0059; 0060. . Retrieved 2016/10/17.