4-(1-ethoxy-3,3-difluoroallylidene)-1-tosylpiperidine

Base Information

Chemical Name:4-(1-ethoxy-3,3-difluoroallylidene)-1-tosylpiperidine
CAS No.:1609975-11-2
Molecular Formula:C₁₇H₂₁F₂NO₃S
Molecular Weight:357.421
Hs Code.:

Synonyms:4-(1-ethoxy-3,3-difluoroallylidene)-1-tosylpiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(1-ethoxy-3,3-difluoroallylidene)-1-tosylpiperidine

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Technology Process of 4-(1-ethoxy-3,3-difluoroallylidene)-1-tosylpiperidine

There total 4 articles about 4-(1-ethoxy-3,3-difluoroallylidene)-1-tosylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1609975-10-1
4-(3-chloro-1-ethoxy-3,3-difluoropropylidene)-1-tosylpiperidine

: 1609975-11-2
4-(1-ethoxy-3,3-difluoroallylidene)-1-tosylpiperidine

Guidance literature:: With 1,8-diazabicyclo[5.4.0]undec-7-ene; at 45 - 50 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol501063a

Reference yield:

: 1609975-09-8
2-(4-(1-ethoxyvinyl)-1-tosylpiperidin-4-yloxy)-6-fluoropyridine

: 1609975-11-2
4-(1-ethoxy-3,3-difluoroallylidene)-1-tosylpiperidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: dilauryl peroxide / ethyl acetate / 2.25 h / Inert atmosphere; Reflux

1.2: 1 h / Inert atmosphere

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 2 h / 45 - 50 °C / Inert atmosphere

With dilauryl peroxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In ethyl acetate;
DOI:10.1021/ol501063a

Reference yield:

: 1609975-08-7
C₁₆H₂₃NO₄S

: 1609975-11-2
4-(1-ethoxy-3,3-difluoroallylidene)-1-tosylpiperidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 60 °C / Inert atmosphere

2.1: dilauryl peroxide / ethyl acetate / 2.25 h / Inert atmosphere; Reflux

2.2: 1 h / Inert atmosphere

3.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / 2 h / 45 - 50 °C / Inert atmosphere

With dilauryl peroxide; sodium hydride; 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; ethyl acetate; mineral oil;
DOI:10.1021/ol501063a