Technology Process of (2R)-3-[(tert-butoxycarbonyl)amino]-2-{4-[(diethoxyphosphoryl)methyl]benzyl}propyl acetate
There total 7 articles about (2R)-3-[(tert-butoxycarbonyl)amino]-2-{4-[(diethoxyphosphoryl)methyl]benzyl}propyl acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
ethyl acetate;
at 20 ℃;
for 2h;
under 760 Torr;
DOI:10.1016/S0040-4020(98)00586-9
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 76 percent / NaH / tetrahydrofuran / 0.5 h / 20 °C
2: 79 percent / NaBH4 / methanol / 2 h / 20 °C
3: 97 percent / lipase PS / tetrahydrofuran / 2 h / 25 °C / Enzymatic reaction; 2 equiv. vinyl acetate
4: HN3; diisopropyl azodicarboxylate; Ph3P / benzene; aq. H2SO4 / -35 - 20 °C
5: 98 percent / H2 / Pd-C / ethyl acetate / 2 h / 20 °C / 760 Torr
With
sodium tetrahydroborate; Lipase PS; tris-(2-chloro-ethyl)-amine; di-isopropyl azodicarboxylate; hydrogen; sodium hydride; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; sulfuric acid; ethyl acetate; benzene;
1: Substitution / 2: Reduction / 3: Acetylation / 4: Substitution / 5: Hydrogenation;
DOI:10.1016/S0040-4020(98)00586-9
- Guidance literature:
-
Multi-step reaction with 6 steps
1: N-bromosuccinimide; AIBN / CCl4 / 3 h / 90 °C
2: 76 percent / NaH / tetrahydrofuran / 0.5 h / 20 °C
3: 79 percent / NaBH4 / methanol / 2 h / 20 °C
4: 97 percent / lipase PS / tetrahydrofuran / 2 h / 25 °C / Enzymatic reaction; 2 equiv. vinyl acetate
5: HN3; diisopropyl azodicarboxylate; Ph3P / benzene; aq. H2SO4 / -35 - 20 °C
6: 98 percent / H2 / Pd-C / ethyl acetate / 2 h / 20 °C / 760 Torr
With
sodium tetrahydroborate; N-Bromosuccinimide; Lipase PS; 2,2'-azobis(isobutyronitrile); tris-(2-chloro-ethyl)-amine; di-isopropyl azodicarboxylate; hydrogen; sodium hydride; triphenylphosphine;
palladium on activated charcoal;
In
tetrahydrofuran; methanol; tetrachloromethane; sulfuric acid; ethyl acetate; benzene;
1: Bromination / 2: Substitution / 3: Reduction / 4: Acetylation / 5: Substitution / 6: Hydrogenation;
DOI:10.1016/S0040-4020(98)00586-9
