Technology Process of (2R,3S,6R,8S,10S)-10-benzyloxy-8-benzyloxymethyl-2-isopropyl-3-methyl-1,7-dioxaspiro<5.5>undec-4-ene
There total 15 articles about (2R,3S,6R,8S,10S)-10-benzyloxy-8-benzyloxymethyl-2-isopropyl-3-methyl-1,7-dioxaspiro<5.5>undec-4-ene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 100 percent / H2, quinoline / Pd/CaCO3/Pb / methanol
2: camphorsulphonic acid / diethyl ether
With
quinoline; camphor-10-sulfonic acid; hydrogen;
Lindlar's catalyst;
In
methanol; diethyl ether;
DOI:10.1039/c39850000309
- Guidance literature:
-
Multi-step reaction with 13 steps
1: 59 percent / t-BuOOH, (-)-diethyl tartrate, Ti(OPr)4
3: pyridine
4: imidazole, 4-N,N-dimethylaminopyridine / dimethylformamide / 50 °C
5: KOH / methanol
6: 84 percent / (COCl)2, DMSO, Et3N
7: PPh3 / CH2Cl2
8: n-BuLi / tetrahydrofuran
9: 1.) n-BuLi / 1.) THF, -78 deg C
10: Amberlyst H(+)
11: n-Bu4NF / tetrahydrofuran
12: 100 percent / H2, quinoline / Pd/CaCO3/Pb / methanol
13: camphorsulphonic acid / diethyl ether
With
pyridine; 1H-imidazole; quinoline; titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; potassium hydroxide; n-butyllithium; oxalyl dichloride; Amberlyst H(+); camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; dimethyl sulfoxide; (-)-diethyl tartrate; triethylamine; triphenylphosphine;
Lindlar's catalyst;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c39850000309
- Guidance literature:
-
Multi-step reaction with 14 steps
1: 86 percent / DIBAL-H / diethyl ether / -78 °C
2: 59 percent / t-BuOOH, (-)-diethyl tartrate, Ti(OPr)4
4: pyridine
5: imidazole, 4-N,N-dimethylaminopyridine / dimethylformamide / 50 °C
6: KOH / methanol
7: 84 percent / (COCl)2, DMSO, Et3N
8: PPh3 / CH2Cl2
9: n-BuLi / tetrahydrofuran
10: 1.) n-BuLi / 1.) THF, -78 deg C
11: Amberlyst H(+)
12: n-Bu4NF / tetrahydrofuran
13: 100 percent / H2, quinoline / Pd/CaCO3/Pb / methanol
14: camphorsulphonic acid / diethyl ether
With
pyridine; 1H-imidazole; quinoline; titanium(IV) isopropylate; tert.-butylhydroperoxide; dmap; potassium hydroxide; n-butyllithium; oxalyl dichloride; Amberlyst H(+); camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; diisobutylaluminium hydride; dimethyl sulfoxide; (-)-diethyl tartrate; triethylamine; triphenylphosphine;
Lindlar's catalyst;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/c39850000309
