N₁-5-[4-([(5-methyl-3-isoxazolyl)amino]carbonylamino)phenyl]-1,3-thiazol-2-yl-4-(2-morpholinoethoxy)benzamide

Base Information

• Chemical Name: N₁-5-[4-([(5-methyl-3-isoxazolyl)amino]carbonylamino)phenyl]-1,3-thiazol-2-yl-4-(2-morpholinoethoxy)benzamide
• CAS No.: 1395051-45-2
• Molecular Formula: C₂₇H₂₈N₆O₅S
• Molecular Weight: 548.623
• Mol file: 1395051-45-2.mol

Synonyms:N₁-5-[4-([(5-methyl-3-isoxazolyl)amino]carbonylamino)phenyl]-1,3-thiazol-2-yl-4-(2-morpholinoethoxy)benzamide

Chemical Property of N₁-5-[4-([(5-methyl-3-isoxazolyl)amino]carbonylamino)phenyl]-1,3-thiazol-2-yl-4-(2-morpholinoethoxy)benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N₁-5-[4-([(5-methyl-3-isoxazolyl)amino]carbonylamino)phenyl]-1,3-thiazol-2-yl-4-(2-morpholinoethoxy)benzamide

There total 3 articles about N₁-5-[4-([(5-methyl-3-isoxazolyl)amino]carbonylamino)phenyl]-1,3-thiazol-2-yl-4-(2-morpholinoethoxy)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(5-methylisoxazol-3-yl)carbamic acid 4-nitro-phenyl ester (1035700-05-0) + C22H24N4O3S → N1-5-[4-([(5-methyl-3-isoxazolyl)amino]carbonylamino)phenyl]-1,3-thiazol-2-yl-4-(2-morpholinoethoxy)benzamide (1395051-45-2)

Guidance literature:

With pyridine; at 20 ℃; for 2h;

DOI:10.1016/j.ejmech.2015.05.008

Reference yield:

4-[2-(morpholin-4-yl)ethoxy]benzoyl chloride + 5-(4-aminophenyl)-2-amino-1,3-thiazole (90349-87-4) → N1-5-[4-([(5-methyl-3-isoxazolyl)amino]carbonylamino)phenyl]-1,3-thiazol-2-yl-4-(2-morpholinoethoxy)benzamide (1395051-45-2)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine / 2 h / 20 °C

2: pyridine / 2 h / 20 °C

With pyridine;

DOI:10.1016/j.ejmech.2015.05.008

Reference yield:

→ N1-5-[4-([(5-methyl-3-isoxazolyl)amino]carbonylamino)phenyl]-1,3-thiazol-2-yl-4-(2-morpholinoethoxy)benzamide (1395051-45-2)

Guidance literature:

With pyridine; In dimethyl sulfoxide; for 0.5h;

upstream raw materials:

(5-methylisoxazol-3-yl)carbamic acid 4-nitro-phenyl ester

5-(4-aminophenyl)-2-amino-1,3-thiazole