Technology Process of Benzyl-[2-(5,6,4'-trimethoxy-biphenyl-2-yl)-ethyl]-amine
There total 6 articles about Benzyl-[2-(5,6,4'-trimethoxy-biphenyl-2-yl)-ethyl]-amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 92 percent / conc. aq. HCl / toluene / 1 h / 100 °C
2: 95 percent / dimethylsulfoxide / 1 h / Ambient temperature
3: 98 percent / NH3, H2 / Raney Ni / methanol / 3 h / 50 °C / 2585.7 Torr
4: 2.) KBH4 / 1.) ethanol, RT, 15 min, 2.) ethanol, water, RT, 3 h
With
hydrogenchloride; potassium borohydride; ammonia; hydrogen;
nickel;
In
methanol; dimethyl sulfoxide; toluene;
DOI:10.1021/jm00160a018
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 95 percent / dimethylsulfoxide / 1 h / Ambient temperature
2: 98 percent / NH3, H2 / Raney Ni / methanol / 3 h / 50 °C / 2585.7 Torr
3: 2.) KBH4 / 1.) ethanol, RT, 15 min, 2.) ethanol, water, RT, 3 h
With
potassium borohydride; ammonia; hydrogen;
nickel;
In
methanol; dimethyl sulfoxide;
DOI:10.1021/jm00160a018
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 95 percent / LiAlH4 / tetrahydrofuran / 4 h / Heating
2: 92 percent / conc. aq. HCl / toluene / 1 h / 100 °C
3: 95 percent / dimethylsulfoxide / 1 h / Ambient temperature
4: 98 percent / NH3, H2 / Raney Ni / methanol / 3 h / 50 °C / 2585.7 Torr
5: 2.) KBH4 / 1.) ethanol, RT, 15 min, 2.) ethanol, water, RT, 3 h
With
hydrogenchloride; lithium aluminium tetrahydride; potassium borohydride; ammonia; hydrogen;
nickel;
In
tetrahydrofuran; methanol; dimethyl sulfoxide; toluene;
DOI:10.1021/jm00160a018
