(1H-benzo[d]imidazol-2-yl)(3,4,5-trimethoxyphenyl)-methanone

Base Information

• Chemical Name: (1H-benzo[d]imidazol-2-yl)(3,4,5-trimethoxyphenyl)-methanone
• CAS No.: 1332526-46-1
• Molecular Formula: C₁₇H₁₆N₂O₄
• Molecular Weight: 312.325
• Mol file: 1332526-46-1.mol

Synonyms:(1H-benzo[d]imidazol-2-yl)(3,4,5-trimethoxyphenyl)-methanone

Chemical Property of (1H-benzo[d]imidazol-2-yl)(3,4,5-trimethoxyphenyl)-methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1H-benzo[d]imidazol-2-yl)(3,4,5-trimethoxyphenyl)-methanone

There total 3 articles about (1H-benzo[d]imidazol-2-yl)(3,4,5-trimethoxyphenyl)-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 12.7%

(1-(phenylsulfonyl)-1H-benzo[d]imidazol-2-yl)(3,4,5-trimethoxyphenyl)methanone (1332526-39-2) → (1H-benzo[d]imidazol-2-yl)(3,4,5-trimethoxyphenyl)-methanone (1332526-46-1)

Guidance literature:

With ethanol; sodium hydroxide; Darkness;

DOI:10.1016/j.bmc.2011.06.084

Reference yield:

1-(phenylsulfonyl)-1H-benzo[d]imidazole (15728-43-5) → (1H-benzo[d]imidazol-2-yl)(3,4,5-trimethoxyphenyl)-methanone (1332526-46-1)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / Inert atmosphere

1.2: -78 °C / Inert atmosphere

2.1: ethanol; sodium hydroxide / Darkness

With ethanol; tert.-butyl lithium; sodium hydroxide; In tetrahydrofuran; pentane;

DOI:10.1016/j.bmc.2011.06.084

Reference yield:

benzoimidazole (51-17-2,79351-71-6) → (1H-benzo[d]imidazol-2-yl)(3,4,5-trimethoxyphenyl)-methanone (1332526-46-1)

Guidance literature:

Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C / Inert atmosphere

1.2: 0 - 20 °C / Inert atmosphere

2.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / Inert atmosphere

2.2: -78 °C / Inert atmosphere

3.1: ethanol; sodium hydroxide / Darkness

With ethanol; tert.-butyl lithium; sodium hydride; sodium hydroxide; In tetrahydrofuran; mineral oil; pentane;

DOI:10.1016/j.bmc.2011.06.084

upstream raw materials:

benzoimidazole

(1-(phenylsulfonyl)-1H-benzo[d]imidazol-2-yl)(3,4,5-trimethoxyphenyl)methanone

1-(phenylsulfonyl)-1H-benzo[d]imidazole