(2E,4S,5R,6R,8R)-8-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-6-hydroxy-5-(4-methoxybenzyloxy)-4,6-dimethyl-2-nonene

Base Information

Chemical Name:(2E,4S,5R,6R,8R)-8-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-6-hydroxy-5-(4-methoxybenzyloxy)-4,6-dimethyl-2-nonene
CAS No.:160429-76-5
Molecular Formula:C₄₁H₆₀O₈
Molecular Weight:680.923
Hs Code.:

(2E,4S,5R,6R,8R)-8-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-6-hydroxy-5-(4-methoxybenzyloxy)-4,6-dimethyl-2-nonene

Synonyms:(2E,4S,5R,6R,8R)-8-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-6-hydroxy-5-(4-methoxybenzyloxy)-4,6-dimethyl-2-nonene

Suppliers and Price of (2E,4S,5R,6R,8R)-8-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-6-hydroxy-5-(4-methoxybenzyloxy)-4,6-dimethyl-2-nonene

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Chemical Property of (2E,4S,5R,6R,8R)-8-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-6-hydroxy-5-(4-methoxybenzyloxy)-4,6-dimethyl-2-nonene

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Technology Process of (2E,4S,5R,6R,8R)-8-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-6-hydroxy-5-(4-methoxybenzyloxy)-4,6-dimethyl-2-nonene

There total 14 articles about (2E,4S,5R,6R,8R)-8-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-6-hydroxy-5-(4-methoxybenzyloxy)-4,6-dimethyl-2-nonene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 160429-75-4
(2E,4R,5R,6R,8R)-8-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-5,6-dihydroxy-4,6-dimethyl-2-nonene

: 824-94-2
p-methoxybenzyl chloride

: 160429-76-5
(2E,4S,5R,6R,8R)-8-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-6-hydroxy-5-(4-methoxybenzyloxy)-4,6-dimethyl-2-nonene

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide;

Reference yield:

: 147033-10-1
(2R,3S)-2-ethyl-3-<<(2R,4S,3S,5S,6R)-2-(4-methoxyphenyl)-5-methyl-4-<(1R,2E)-1-methyl-2-butenyl>>-1,3-dioxan-6-yl>-3-methyl-1,4-dioxaspiro<4.4>nonane

: 160429-76-5
(2E,4S,5R,6R,8R)-8-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-6-hydroxy-5-(4-methoxybenzyloxy)-4,6-dimethyl-2-nonene

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) O₃/O₂; 2.) Ph₃P / 1.) CH₂Cl₂, -78 deg C; 2.) CH₂Cl₂, -78 deg C to 0 deg C

2: 91 percent / CH₂Cl₂ / 24 h / Ambient temperature

3: 99 percent / LiAlH₄ / diethyl ether / 6 h / Heating

5: 1.) 0.35M iPrMgBr; 2.) LiAlH₄ / 1.) THF, 30 min; 2.) THF, reflux, 6 h

6: 72 percent / 80percent NaH/white oil / dimethylformamide / 24 h

With lithium aluminium tetrahydride; isopropylmagnesium bromide; oxygen; sodium hydride; ozone; triphenylphosphine; white oil; In diethyl ether; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 160429-72-1
ethyl (2E,4R)-4-<(2R,4S,5S,6R)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-2-methyl-2-pentenoate

: 160429-76-5
(2E,4S,5R,6R,8R)-8-<(2R,4R,5S,6S)-6-<(2R,3S)-2-ethyl-3-methyl-1,4-dioxaspiro<4.4>nonan-3-yl>-4-<2-(4-methoxyphenyl)-5-methyl-1,3-dioxan-4-yl>>-6-hydroxy-5-(4-methoxybenzyloxy)-4,6-dimethyl-2-nonene

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / LiAlH₄ / diethyl ether / 6 h / Heating

3: 1.) 0.35M iPrMgBr; 2.) LiAlH₄ / 1.) THF, 30 min; 2.) THF, reflux, 6 h

4: 72 percent / 80percent NaH/white oil / dimethylformamide / 24 h

With lithium aluminium tetrahydride; isopropylmagnesium bromide; sodium hydride; white oil; In diethyl ether; N,N-dimethyl-formamide;