(R)-4-{(3R,5R,8R,9S,10S,13R,14S,17R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

Base Information

Chemical Name:(R)-4-{(3R,5R,8R,9S,10S,13R,14S,17R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester
CAS No.:198974-68-4
Molecular Formula:C₄₈H₆₉N₃O₆
Molecular Weight:784.092
Hs Code.:

(R)-4-{(3R,5R,8R,9S,10S,13R,14S,17R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

Synonyms:(R)-4-{(3R,5R,8R,9S,10S,13R,14S,17R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

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Chemical Property of (R)-4-{(3R,5R,8R,9S,10S,13R,14S,17R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

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Technology Process of (R)-4-{(3R,5R,8R,9S,10S,13R,14S,17R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

There total 1 articles about (R)-4-{(3R,5R,8R,9S,10S,13R,14S,17R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 13122-90-2
Boc-Phe-Phe-OH

: (R)-4-((3R,5R,8R,9S,10S,13R,14S,17R)-3-Amino-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl)-pentanoic acid methyl ester; hydrochloride

: 198974-68-4
(R)-4-{(3R,5R,8R,9S,10S,13R,14S,17R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

Guidance literature:: With diethyl cyanophosphonate; triethylamine; In N,N-dimethyl-formamide; for 48h; Ambient temperature;
DOI:10.1002/hlca.19970800716

Reference yield:

: 198974-68-4
(R)-4-{(3R,5R,8R,9S,10S,13R,14S,17R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

: (R)-4-{(3R,5R,8R,9S,10S,13R,14S,17R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid

Guidance literature:: With sodium hydroxide; In ethanol; for 5h;
DOI:10.1002/hlca.19970800716

Reference yield:

: 198974-68-4
(R)-4-{(3R,5R,8R,9S,10S,13R,14S,17R)-3-[(S)-2-((S)-2-tert-Butoxycarbonylamino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid methyl ester

: 218621-39-7
(R)-4-{(3R,5R,8R,9S,10S,13R,14S,17R)-3-[(S)-2-((S)-2-Amino-3-phenyl-propionylamino)-3-phenyl-propionylamino]-10,13-dimethyl-hexadecahydro-cyclopenta[a]phenanthren-17-yl}-pentanoic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1N aq.NaOH / ethanol / 5 h

2: dicyclohexylcarbodiimide / CH₂Cl₂ / Ambient temperature

3: CF₃COOH / 1 h

With sodium hydroxide; dicyclohexyl-carbodiimide; trifluoroacetic acid; In ethanol; dichloromethane;
DOI:10.1002/hlca.19970800716