4-(tert-butyl)-2-(3-hydroxyprop-1-yn-1-yl)phenyl trifluoromethanesulfonate

Base Information

Chemical Name:4-(tert-butyl)-2-(3-hydroxyprop-1-yn-1-yl)phenyl trifluoromethanesulfonate
CAS No.:1263272-28-1
Molecular Formula:C₁₄H₁₅F₃O₄S
Molecular Weight:336.332
Hs Code.:

Synonyms:4-(tert-butyl)-2-(3-hydroxyprop-1-yn-1-yl)phenyl trifluoromethanesulfonate

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Chemical Property of 4-(tert-butyl)-2-(3-hydroxyprop-1-yn-1-yl)phenyl trifluoromethanesulfonate

Chemical Property:

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Technology Process of 4-(tert-butyl)-2-(3-hydroxyprop-1-yn-1-yl)phenyl trifluoromethanesulfonate

There total 1 articles about 4-(tert-butyl)-2-(3-hydroxyprop-1-yn-1-yl)phenyl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 217966-72-8
4-(tert-butyl)-2-iodophenyltrifluoromethane sulfonate

: 107-19-7
propargyl alcohol

: 1263272-28-1
4-(tert-butyl)-2-(3-hydroxyprop-1-yn-1-yl)phenyl trifluoromethanesulfonate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine; In tetrahydrofuran; at 20 ℃; for 8h; Inert atmosphere;
DOI:10.1039/c0cc02177f

Reference yield: 87.0%

: 1263272-28-1
4-(tert-butyl)-2-(3-hydroxyprop-1-yn-1-yl)phenyl trifluoromethanesulfonate

: 89343-06-6
tris-iso-propylsilyl acetylene

: 1263272-29-2
3-(5-(tert-butyl)-2-((triisopropylsilyl)ethynyl)phenyl)prop-2-yn-1-ol

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; diisopropylamine; In N,N-dimethyl-formamide; at 80 ℃; for 24h; Inert atmosphere;
DOI:10.1039/c0cc02177f

Reference yield:

: 1263272-28-1
4-(tert-butyl)-2-(3-hydroxyprop-1-yn-1-yl)phenyl trifluoromethanesulfonate

: 1263272-30-5
3-(5-(tert-butyl)-2-ethynylphenyl)prop-2-yn-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; diisopropylamine / N,N-dimethyl-formamide / 24 h / 80 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 5.08 h / 0 - 20 °C / Inert atmosphere

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; tetrabutyl ammonium fluoride; diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1039/c0cc02177f