1-[2-(4-Azido-phenyl)-1,1-dimethyl-ethylamino]-3-(1-iodo-9H-carbazol-4-yloxy)-propan-2-ol

Base Information

Chemical Name:1-[2-(4-Azido-phenyl)-1,1-dimethyl-ethylamino]-3-(1-iodo-9H-carbazol-4-yloxy)-propan-2-ol
CAS No.:85135-31-5
Molecular Formula:C₂₅H₂₆IN₅O₂
Molecular Weight:555.418
Hs Code.:

Synonyms:1-[2-(4-Azido-phenyl)-1,1-dimethyl-ethylamino]-3-(1-iodo-9H-carbazol-4-yloxy)-propan-2-ol

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Chemical Property of 1-[2-(4-Azido-phenyl)-1,1-dimethyl-ethylamino]-3-(1-iodo-9H-carbazol-4-yloxy)-propan-2-ol

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Technology Process of 1-[2-(4-Azido-phenyl)-1,1-dimethyl-ethylamino]-3-(1-iodo-9H-carbazol-4-yloxy)-propan-2-ol

There total 4 articles about 1-[2-(4-Azido-phenyl)-1,1-dimethyl-ethylamino]-3-(1-iodo-9H-carbazol-4-yloxy)-propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 82408-66-0
(+/-)-15-(4-nitrobenzyl)carazolol

: 85135-31-5
1-[2-(4-Azido-phenyl)-1,1-dimethyl-ethylamino]-3-(1-iodo-9H-carbazol-4-yloxy)-propan-2-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / conc. HCl, H₂ / 5percent Pd/C / methanol / 1.5 h / 2844.3 Torr

2: NaOH, chloramine T, NaI / dioxane; aq. HCl; H₂O / 0.08 h / sodium acetate buffer pH 5.6

3: 1.) AcOH, NaNO₂, 2.) NaN₃ / 1.) H₂O, 0 deg C, 20 min, 2.) H₂O, RT, 20 min

With hydrogenchloride; sodium hydroxide; sodium azide; hydrogen; chloroamine-T; acetic acid; sodium iodide; sodium nitrite; palladium on activated charcoal; In 1,4-dioxane; hydrogenchloride; methanol; water;
DOI:10.1021/jm00360a009

Reference yield:

: 51997-51-4,95093-96-2
4-(2,3-epoxypropoxy)carbazole

: 85135-31-5
1-[2-(4-Azido-phenyl)-1,1-dimethyl-ethylamino]-3-(1-iodo-9H-carbazol-4-yloxy)-propan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 72 percent / ethanol / 72 h / 65 °C

2: 82 percent / conc. HCl, H₂ / 5percent Pd/C / methanol / 1.5 h / 2844.3 Torr

3: NaOH, chloramine T, NaI / dioxane; aq. HCl; H₂O / 0.08 h / sodium acetate buffer pH 5.6

4: 1.) AcOH, NaNO₂, 2.) NaN₃ / 1.) H₂O, 0 deg C, 20 min, 2.) H₂O, RT, 20 min

With hydrogenchloride; sodium hydroxide; sodium azide; hydrogen; chloroamine-T; acetic acid; sodium iodide; sodium nitrite; palladium on activated charcoal; In 1,4-dioxane; hydrogenchloride; methanol; ethanol; water;
DOI:10.1021/jm00360a009

Reference yield:

: 97458-55-4,82408-63-7
(+/-)-15-(4-aminobenzyl)carazolol

: 85135-31-5
1-[2-(4-Azido-phenyl)-1,1-dimethyl-ethylamino]-3-(1-iodo-9H-carbazol-4-yloxy)-propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH, chloramine T, NaI / dioxane; aq. HCl; H₂O / 0.08 h / sodium acetate buffer pH 5.6

2: 1.) AcOH, NaNO₂, 2.) NaN₃ / 1.) H₂O, 0 deg C, 20 min, 2.) H₂O, RT, 20 min

With sodium hydroxide; sodium azide; chloroamine-T; acetic acid; sodium iodide; sodium nitrite; In 1,4-dioxane; hydrogenchloride; water;
DOI:10.1021/jm00360a009