4-phenyl-1-[2-(4-trifluoromethoxyanilino)ethyl]-1,2,3,6-tetrahydropyridine

Base Information

Chemical Name:4-phenyl-1-[2-(4-trifluoromethoxyanilino)ethyl]-1,2,3,6-tetrahydropyridine
CAS No.:133783-63-8
Molecular Formula:C₂₀H₂₁F₃N₂O
Molecular Weight:362.395
Hs Code.:

Synonyms:4-phenyl-1-[2-(4-trifluoromethoxyanilino)ethyl]-1,2,3,6-tetrahydropyridine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-phenyl-1-[2-(4-trifluoromethoxyanilino)ethyl]-1,2,3,6-tetrahydropyridine

Chemical Property:

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Technology Process of 4-phenyl-1-[2-(4-trifluoromethoxyanilino)ethyl]-1,2,3,6-tetrahydropyridine

There total 4 articles about 4-phenyl-1-[2-(4-trifluoromethoxyanilino)ethyl]-1,2,3,6-tetrahydropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 10338-69-9
1,2,3,6-tetrahydro-4-phenylpyridine

: 98-59-9
p-toluenesulfonyl chloride

: 133783-52-5
2-amino-2-[4-(trifluoromethoxy)phenyl]ethanol

: 133783-64-9
N-(p-toluenesulphonyl)-2-(4-trifluoromethoxyanilino)ethyl p-toluenesulphonate

: 133783-63-8
4-phenyl-1-[2-(4-trifluoromethoxyanilino)ethyl]-1,2,3,6-tetrahydropyridine

Guidance literature:: With sodium bicarbonate; triethylamine; In N-methyl-acetamide; dichloromethane;

Reference yield:

: 461-82-5
4-(trifluoromethoxy)aniline

: 133783-63-8
4-phenyl-1-[2-(4-trifluoromethoxyanilino)ethyl]-1,2,3,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 49 percent / 1.5 h / 160 °C

2: 55 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 °C

3: 1.) NaHCO₃, 2.) aq. HCl, AcOH / 1.) DMF, 80 deg C, 18 h, 2.) 110 deg C, 3 h

With hydrogenchloride; sodium hydrogencarbonate; acetic acid; triethylamine; In dichloromethane;
DOI:10.1021/jm980202u

Reference yield:

: 133783-52-5
2-amino-2-[4-(trifluoromethoxy)phenyl]ethanol

: 133783-63-8
4-phenyl-1-[2-(4-trifluoromethoxyanilino)ethyl]-1,2,3,6-tetrahydropyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 55 percent / Et₃N / CH₂Cl₂ / 1.5 h / 0 °C

2: 1.) NaHCO₃, 2.) aq. HCl, AcOH / 1.) DMF, 80 deg C, 18 h, 2.) 110 deg C, 3 h

With hydrogenchloride; sodium hydrogencarbonate; acetic acid; triethylamine; In dichloromethane;
DOI:10.1021/jm980202u