N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)quinoline-3-sulfonamide

Base Information

Chemical Name:N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)quinoline-3-sulfonamide
CAS No.:1445879-77-5
Molecular Formula:C₃₀H₂₉FN₆O₅S₂
Molecular Weight:636.728
Hs Code.:

Synonyms:N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)quinoline-3-sulfonamide

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Chemical Property of N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)quinoline-3-sulfonamide

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Technology Process of N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)quinoline-3-sulfonamide

There total 10 articles about N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)quinoline-3-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1445880-83-0
3-amino-5-(4-fluorophenoxy)benzenesulfonamide

: 1445880-86-3
4-chloro-N-cyclopropyl-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)quinoline-3-sulfonamide

: 1445879-77-5
N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)quinoline-3-sulfonamide

Guidance literature:: In ethanol; for 2h; Reflux;

Reference yield:

: 82121-06-0
4-hydroxy-7-bromoquinoline

: 1445879-77-5
N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)quinoline-3-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: chlorosulfonic acid / 18 h / 100 °C

2: trichlorophosphate / 3 h / Reflux

3: triethylamine / dichloromethane / 1 h / 0 °C

4: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 3 h / 80 °C

5: ethanol / 2 h / Reflux

With chlorosulfonic acid; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; triethylamine; trichlorophosphate; In 1,4-dioxane; ethanol; dichloromethane; water;

Reference yield:

: 1445879-81-1
7-bromo-4-hydroxy-3-quinolinesulfonyl chloride

: 1445879-77-5
N-cyclopropyl-4-((3-(4-fluorophenoxy)-5-sulfamoylphenyl)amino)-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)quinoline-3-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: trichlorophosphate / 3 h / Reflux

2: triethylamine / dichloromethane / 1 h / 0 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate / 1,4-dioxane; water / 3 h / 80 °C

4: ethanol / 2 h / Reflux

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; triethylamine; trichlorophosphate; In 1,4-dioxane; ethanol; dichloromethane; water;