N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9⁽¹³⁾-en-10-one

Base Information

Chemical Name:N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9⁽¹³⁾-en-10-one
CAS No.:888030-03-3
Molecular Formula:C₂₄H₂₆N₂O₇S
Molecular Weight:486.546
Hs Code.:

N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9<sup>(13)</sup>-en-10-one

Synonyms:N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9⁽¹³⁾-en-10-one

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Chemical Property of N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9⁽¹³⁾-en-10-one

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Technology Process of N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9⁽¹³⁾-en-10-one

There total 17 articles about N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9⁽¹³⁾-en-10-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 888030-11-3
5,13-dimethoxy-10-(2-nitro-benzenesulfonyl)-10-aza-tricyclo[11.2.2.0^2,7]heptadeca-1⁽¹⁶⁾,2⁽⁷⁾,3,5-tetraen-15-ol

: 888030-03-3
N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9⁽¹³⁾-en-10-one

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1021/ol060455e

Reference yield:

: 4-(2-hydroxy-ethyl)-4-methoxy-cyclohexanone

: 888030-03-3
N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9⁽¹³⁾-en-10-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: 3.12 g / imidazole / dimethylformamide / 15 h / 20 °C

2.1: 98 percent / KHMDS / tetrahydrofuran / 4 h / -78 - 20 °C

3.1: DPEphos; triethylamine; pinacolborane / Pd(OAc)2 / CH₂Cl₂ / 1 h / 85 °C

3.2: Cs₂CO₃ / Pd(PPh₃)4 / dimethylsulfoxide / 2 h / 81 °C

3.3: 946 mg / TBAF / tetrahydrofuran / 3 h / 20 °C

4.1: 90 percent / 0.33 h / 165 °C

5.1: 57 percent / triphenylphosphine; diethyl azodicarboxylate / toluene; tetrahydrofuran / 12 h / 20 °C

6.1: 97 percent / m-CPBA / CH₂Cl₂ / 17 h / 20 °C

7.1: 393 mg / tetrafluoroboric acid / CHCl₃ / 22 h / 20 °C

8.1: 253 mg / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

With 1H-imidazole; tetrafluoroboric acid; pinacol borane; potassium hexamethylsilazane; Dess-Martin periodane; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; bis[2-(diphenylphosphino)phenyl] ether; diethylazodicarboxylate; palladium diacetate; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene; 3.2: Suzuki-Miyaura reaction / 5.1: Mitsunobu reaction;
DOI:10.1021/ol060455e

Reference yield:

: 429691-42-9
8-allyl-1,4-dioxaspiro[4.5]decan-8-ol

: 888030-03-3
N-nosyl-4-aza-4'-methoxybenzo[2',1'-g]bicyclo[7.2.2]tridec-9⁽¹³⁾-en-10-one

Guidance literature:: Multi-step reaction with 11 steps

1.1: 95 percent / NaH / tetrahydrofuran; various solvent(s) / 3 h / 20 °C

2.1: ozone / CH₂Cl₂; methanol / -78 °C

2.2: 96 percent / NaBH₄ / CH₂Cl₂; methanol / 4 h / 20 °C

3.1: 68 percent / PPTS / acetone; H₂O / 12 h / Heating

4.1: 3.12 g / imidazole / dimethylformamide / 15 h / 20 °C

5.1: 98 percent / KHMDS / tetrahydrofuran / 4 h / -78 - 20 °C

6.1: DPEphos; triethylamine; pinacolborane / Pd(OAc)2 / CH₂Cl₂ / 1 h / 85 °C

6.2: Cs₂CO₃ / Pd(PPh₃)4 / dimethylsulfoxide / 2 h / 81 °C

6.3: 946 mg / TBAF / tetrahydrofuran / 3 h / 20 °C

7.1: 90 percent / 0.33 h / 165 °C

8.1: 57 percent / triphenylphosphine; diethyl azodicarboxylate / toluene; tetrahydrofuran / 12 h / 20 °C

9.1: 97 percent / m-CPBA / CH₂Cl₂ / 17 h / 20 °C

10.1: 393 mg / tetrafluoroboric acid / CHCl₃ / 22 h / 20 °C

11.1: 253 mg / Dess-Martin periodinane / CH₂Cl₂ / 1 h / 20 °C

With 1H-imidazole; tetrafluoroboric acid; pinacol borane; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; sodium hydride; Dess-Martin periodane; ozone; triethylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; bis[2-(diphenylphosphino)phenyl] ether; diethylazodicarboxylate; palladium diacetate; In tetrahydrofuran; methanol; dichloromethane; chloroform; water; N,N-dimethyl-formamide; acetone; toluene; 6.2: Suzuki-Miyaura reaction / 8.1: Mitsunobu reaction;
DOI:10.1021/ol060455e