Technology Process of 3-(1-methoxypiperidin-4-yl)-2-[2-(2,4,6-trimethyl-phenyl)acetoxy]propionic acid methyl ester
There total 7 articles about 3-(1-methoxypiperidin-4-yl)-2-[2-(2,4,6-trimethyl-phenyl)acetoxy]propionic acid methyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
toluene;
for 6h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere
2.1: oxalyl dichloride; triethylamine / dichloromethane; dimethyl sulfoxide / 0.5 h / -78 °C
3.1: sodium hydrogensulfite / water / 0.5 h / 20 °C
3.2: 10 h / 20 °C
4.1: hydrogenchloride / water / 3 h / 20 °C / Reflux
5.1: toluene / 6 h / Reflux
With
hydrogenchloride; lithium aluminium tetrahydride; oxalyl dichloride; sodium hydrogensulfite; triethylamine;
In
tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; toluene;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: oxalyl dichloride; triethylamine / dichloromethane; dimethyl sulfoxide / 0.5 h / -78 °C
2.1: sodium hydrogensulfite / water / 0.5 h / 20 °C
2.2: 10 h / 20 °C
3.1: hydrogenchloride / water / 3 h / 20 °C / Reflux
4.1: toluene / 6 h / Reflux
With
hydrogenchloride; oxalyl dichloride; sodium hydrogensulfite; triethylamine;
In
dichloromethane; water; dimethyl sulfoxide; toluene;