5-(4-(hydroxymethyl)thiazol-2-ylamino)-3-methyl-7-(4-morpholinophenyl)pyrido[4,3-d]pyrimidin-4(3H)-one

Base Information

Chemical Name:5-(4-(hydroxymethyl)thiazol-2-ylamino)-3-methyl-7-(4-morpholinophenyl)pyrido[4,3-d]pyrimidin-4(3H)-one
CAS No.:1263075-38-2
Molecular Formula:C₂₂H₂₂N₆O₃S
Molecular Weight:450.521
Hs Code.:

Synonyms:5-(4-(hydroxymethyl)thiazol-2-ylamino)-3-methyl-7-(4-morpholinophenyl)pyrido[4,3-d]pyrimidin-4(3H)-one

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Chemical Property of 5-(4-(hydroxymethyl)thiazol-2-ylamino)-3-methyl-7-(4-morpholinophenyl)pyrido[4,3-d]pyrimidin-4(3H)-one

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Technology Process of 5-(4-(hydroxymethyl)thiazol-2-ylamino)-3-methyl-7-(4-morpholinophenyl)pyrido[4,3-d]pyrimidin-4(3H)-one

There total 5 articles about 5-(4-(hydroxymethyl)thiazol-2-ylamino)-3-methyl-7-(4-morpholinophenyl)pyrido[4,3-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 568577-88-8
4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine

: 1263077-33-3
7-chloro-5-(4-(hydroxymethyl)thiazol-2-ylamino)-3-methylpyrido[4,3-d]pyrimidin-4(3H)-one

: 1263075-38-2
5-(4-(hydroxymethyl)thiazol-2-ylamino)-3-methyl-7-(4-morpholinophenyl)pyrido[4,3-d]pyrimidin-4(3H)-one

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 140 ℃; for 0.25h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 918898-03-0
4-amino-2,6-dichloropyridine-3-carboxamide

: 1263075-38-2
5-(4-(hydroxymethyl)thiazol-2-ylamino)-3-methyl-7-(4-morpholinophenyl)pyrido[4,3-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: 6 h / 150 °C / ChemGlass pressure vessel

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

2.2: 14 h / 25 °C

3.1: potassium carbonate / 1,4-dioxane / 80 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.25 h / 140 °C / Microwave irradiation; Inert atmosphere

With sodium hydride; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil; 4.1: Suzuki Coupling;

Reference yield:

: (x)C₂HF₃O₂*C₆H₄Cl₂N₂O₂

: 1263075-38-2
5-(4-(hydroxymethyl)thiazol-2-ylamino)-3-methyl-7-(4-morpholinophenyl)pyrido[4,3-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: thionyl chloride / 0.83 h / Reflux

1.2: 17 h / 0 - 20 °C

2.1: 6 h / 150 °C / ChemGlass pressure vessel

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

3.2: 14 h / 25 °C

4.1: potassium carbonate / 1,4-dioxane / 80 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane; water / 0.25 h / 140 °C / Microwave irradiation; Inert atmosphere

With thionyl chloride; sodium hydride; sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; N,N-dimethyl-formamide; mineral oil; 5.1: Suzuki Coupling;