(2R,3R,4R)-3-benzoyloxy-5-tert-butyldimethylsilyloxy-2,4-dimethylpentan-1-ol

Base Information

Chemical Name:(2R,3R,4R)-3-benzoyloxy-5-tert-butyldimethylsilyloxy-2,4-dimethylpentan-1-ol
CAS No.:916913-28-5
Molecular Formula:C₂₀H₃₄O₄Si
Molecular Weight:366.573
Hs Code.:

Synonyms:(2R,3R,4R)-3-benzoyloxy-5-tert-butyldimethylsilyloxy-2,4-dimethylpentan-1-ol

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Chemical Property of (2R,3R,4R)-3-benzoyloxy-5-tert-butyldimethylsilyloxy-2,4-dimethylpentan-1-ol

Chemical Property:

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Technology Process of (2R,3R,4R)-3-benzoyloxy-5-tert-butyldimethylsilyloxy-2,4-dimethylpentan-1-ol

There total 4 articles about (2R,3R,4R)-3-benzoyloxy-5-tert-butyldimethylsilyloxy-2,4-dimethylpentan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: (2S,3S,4R)-3-benzoyloxy-1-tert-butyldimethylsilyloxy-2,4-dimethylpentyl phenyl sulfoxide

: 916913-28-5
(2R,3R,4R)-3-benzoyloxy-5-tert-butyldimethylsilyloxy-2,4-dimethylpentan-1-ol

Guidance literature:: (2S,3S,4R)-3-benzoyloxy-1-tert-butyldimethylsilyloxy-2,4-dimethylpentyl phenyl sulfoxide; With triethylamine; trifluoroacetic anhydride; In acetonitrile; at 20 ℃; for 0.166667h;

With sodium tetrahydroborate; sodium hydrogencarbonate; In water; acetonitrile; at 20 ℃; for 0.5h;

Reference yield:

: 916913-15-0
(2R,3S,4S)-2,4-dimethyl-5-phenylsulfinylpentane-1,3-diol

: 916913-28-5
(2R,3R,4R)-3-benzoyloxy-5-tert-butyldimethylsilyloxy-2,4-dimethylpentan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1.1: 95 percent / imidazole / CH₂Cl₂ / 0.5 h / 20 °C

2.1: 90 percent / DCC; DMAP / CH₂Cl₂ / 12 h / 20 °C

3.1: triethylamine; TFAA / acetonitrile / 0.17 h / 20 °C

3.2: 75 percent / sodium hydrocarbonate; sodium borohydride / H₂O; acetonitrile / 0.5 h / 20 °C

With 1H-imidazole; dmap; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic anhydride; In dichloromethane; acetonitrile; 3.1: Pummerer reaction;

Reference yield:

: 916913-17-2
(2R,3S,4S)-1-tert-butyldimethylsilyloxy-2,4-dimethyl-5-phenylsulfinylpentan-3-ol

: 916913-28-5
(2R,3R,4R)-3-benzoyloxy-5-tert-butyldimethylsilyloxy-2,4-dimethylpentan-1-ol

Guidance literature:: Multi-step reaction with 2 steps

1.1: 90 percent / DCC; DMAP / CH₂Cl₂ / 12 h / 20 °C

2.1: triethylamine; TFAA / acetonitrile / 0.17 h / 20 °C

2.2: 75 percent / sodium hydrocarbonate; sodium borohydride / H₂O; acetonitrile / 0.5 h / 20 °C

With dmap; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic anhydride; In dichloromethane; acetonitrile; 2.1: Pummerer reaction;