(E)-(2R,3R)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-methoxy-2-vinyl-pent-4-en-1-ol

Base Information

Chemical Name:(E)-(2R,3R)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-methoxy-2-vinyl-pent-4-en-1-ol
CAS No.:339046-89-8
Molecular Formula:C₂₆H₃₆O₃Si
Molecular Weight:424.656
Hs Code.:

Synonyms:(E)-(2R,3R)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-methoxy-2-vinyl-pent-4-en-1-ol

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Chemical Property of (E)-(2R,3R)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-methoxy-2-vinyl-pent-4-en-1-ol

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Technology Process of (E)-(2R,3R)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-methoxy-2-vinyl-pent-4-en-1-ol

There total 7 articles about (E)-(2R,3R)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-methoxy-2-vinyl-pent-4-en-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methoxymethyl phosphonium chloride

: (2R,3R)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-hydroxymethyl-pent-4-enal

: 339046-89-8
(E)-(2R,3R)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-methoxy-2-vinyl-pent-4-en-1-ol

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at 0 - 20 ℃;
DOI:10.1021/ja004325r

Reference yield:

: 339046-98-9
(2R,3R)-2-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-3-hydroxymethyl-pent-4-enoic acid diethylamide

: 339046-89-8
(E)-(2R,3R)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-methoxy-2-vinyl-pent-4-en-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / xylene / 12 h / Heating

2: 3.2 g / diisobutylaluminum hydride / tetrahydrofuran; hexane / 5 h / -78 °C

3: 2.54 g / KHMDS / toluene; tetrahydrofuran / 0 - 20 °C

With potassium hexamethylsilazane; diisobutylaluminium hydride; In tetrahydrofuran; hexane; toluene; xylene; 3: Wittig reaction;
DOI:10.1021/ja004325r

Reference yield:

: 339046-87-6
3-(tert-butyl-dimethyl-silanyloxymethyl)-2-[2-(tert-butyl-diphenyl-silanyloxy)-ethyl]-pent-4-enoic acid diethylamide

: 339046-89-8
(E)-(2R,3R)-3-[2-(tert-Butyl-diphenyl-silanyloxy)-ethyl]-5-methoxy-2-vinyl-pent-4-en-1-ol

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / PPTS / ethanol / 20 °C

2: 97 percent / xylene / 12 h / Heating

3: 3.2 g / diisobutylaluminum hydride / tetrahydrofuran; hexane / 5 h / -78 °C

4: 2.54 g / KHMDS / toluene; tetrahydrofuran / 0 - 20 °C

With pyridinium p-toluenesulfonate; potassium hexamethylsilazane; diisobutylaluminium hydride; In tetrahydrofuran; ethanol; hexane; toluene; xylene; 4: Wittig reaction;
DOI:10.1021/ja004325r