1-(2-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)pyrrolidin-1-yl)prop-2-en-1-one

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Chemical Name:1-(2-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)pyrrolidin-1-yl)prop-2-en-1-one
CAS No.:1328624-32-3
Molecular Formula:C₂₇H₂₃ClFN₅O₃
Molecular Weight:519.963
Hs Code.:

Synonyms:1-(2-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)pyrrolidin-1-yl)prop-2-en-1-one

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Chemical Property of 1-(2-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)pyrrolidin-1-yl)prop-2-en-1-one

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Technology Process of 1-(2-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)pyrrolidin-1-yl)prop-2-en-1-one

There total 4 articles about 1-(2-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)pyrrolidin-1-yl)prop-2-en-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: N-(3-chloro-4-(3-fluorobenzyloxy)phenyl)-5-(3-(pyrrolidine-2-yl)isoxazol-5-yl)pyrimidin-4-amine

: 814-68-6,25189-84-8
acryloyl chloride

: 1328624-32-3
1-(2-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)pyrrolidin-1-yl)prop-2-en-1-one

Guidance literature:: With sodium hydrogencarbonate; In tetrahydrofuran; water; at 0 ℃; for 1h;

Reference yield:

: (S)-2-(hydroxyiminomethyl)pyrrolidine-1-carboxylic acid tert-butyl ester

: 1328624-32-3
1-(2-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)pyrrolidin-1-yl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: N-chloro-succinimide; pyridine / tetrahydrofuran / 2 h / 20 °C

1.2: 3 h / 65 °C

2.1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

3.1: sodium hydrogencarbonate / water; tetrahydrofuran / 1 h / 0 °C

With pyridine; N-chloro-succinimide; sodium hydrogencarbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;

Reference yield:

: 1328624-33-4
tert-butyl 2-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)pyrrolidine-1-carboxylate

: 1328624-32-3
1-(2-(5-(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)pyrimidin-5-yl)isoxazol-3-yl)pyrrolidin-1-yl)prop-2-en-1-one

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 1 h / 20 °C

2: sodium hydrogencarbonate / water; tetrahydrofuran / 1 h / 0 °C

With sodium hydrogencarbonate; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;