Technology Process of 4-((1R,3S)-6-chloro-3-(phenyl-d5)-indan-1-yl)-1(d3),2,2-trimethylpiperazine fumarate
There total 18 articles about 4-((1R,3S)-6-chloro-3-(phenyl-d5)-indan-1-yl)-1(d3),2,2-trimethylpiperazine fumarate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
In
ethanol; acetone;
at 55 ℃;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: magnesium; sodium bis(2-methoxyethoxy)aluminium dihydride / tetrahydrofuran; toluene / 1.5 h / Inert atmosphere; Reflux
1.2: 1.5 h / 50 °C / Inert atmosphere
2.1: tetrahydrofuran / 2.5 h / 20 - 45 °C / Inert atmosphere
3.1: sodium periodate / tetrahydrofuran; water / 1.5 h / 60 °C / Inert atmosphere
4.1: hydrogen; bis(norbornadiene)rhodium(l)tetrafluoroborate; (2S,3S)-2,3-bis(diphenylphosphino)butane / cis-1,2-Dichloroethylene / 20 °C / 3000.3 Torr
5.1: sodium tetrahydroborate / tetrahydrofuran; isopropyl alcohol / -10 - 20 °C / Inert atmosphere
6.1: thionyl chloride / 2-methyltetrahydrofuran / 1 - 20 °C / Inert atmosphere
7.1: potassium carbonate / 24 h / 90 °C / Inert atmosphere
8.1: acetone; ethanol / 55 °C / Inert atmosphere
With
bis(norbornadiene)rhodium(l)tetrafluoroborate; sodium tetrahydroborate; sodium periodate; thionyl chloride; hydrogen; potassium carbonate; (2S,3S)-2,3-bis(diphenylphosphino)butane; magnesium; sodium bis(2-methoxyethoxy)aluminium dihydride;
In
tetrahydrofuran; 2-methyltetrahydrofuran; cis-1,2-Dichloroethylene; ethanol; water; isopropyl alcohol; acetone; toluene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: tetrahydrofuran / 2.5 h / 20 - 45 °C / Inert atmosphere
2: sodium periodate / tetrahydrofuran; water / 1.5 h / 60 °C / Inert atmosphere
3: hydrogen; bis(norbornadiene)rhodium(l)tetrafluoroborate; (2S,3S)-2,3-bis(diphenylphosphino)butane / cis-1,2-Dichloroethylene / 20 °C / 3000.3 Torr
4: sodium tetrahydroborate / tetrahydrofuran; isopropyl alcohol / -10 - 20 °C / Inert atmosphere
5: thionyl chloride / 2-methyltetrahydrofuran / 1 - 20 °C / Inert atmosphere
6: potassium carbonate / 24 h / 90 °C / Inert atmosphere
7: acetone; ethanol / 55 °C / Inert atmosphere
With
bis(norbornadiene)rhodium(l)tetrafluoroborate; sodium tetrahydroborate; sodium periodate; thionyl chloride; hydrogen; potassium carbonate; (2S,3S)-2,3-bis(diphenylphosphino)butane;
In
tetrahydrofuran; 2-methyltetrahydrofuran; cis-1,2-Dichloroethylene; ethanol; water; isopropyl alcohol; acetone;
