deacetamido-12a,12b-secocolchicin

Base Information

Chemical Name:deacetamido-12a,12b-secocolchicin
CAS No.:153870-98-5
Molecular Formula:C₂₀H₂₄O₅
Molecular Weight:344.408
Hs Code.:

Synonyms:deacetamido-12a,12b-secocolchicin

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Chemical Property of deacetamido-12a,12b-secocolchicin

Chemical Property:

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Technology Process of deacetamido-12a,12b-secocolchicin

There total 18 articles about deacetamido-12a,12b-secocolchicin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 1666-13-3
diphenyl diselenide

: 125730-99-6
(RS)-6-<1'-mesyloxy-3'-(3'',4'',5''-trimethoxyphenyl)propyl>-2-methoxycyclohepta-2,4,6-trienone

: 153870-98-5
deacetamido-12a,12b-secocolchicin

: (RS)-2-methoxy-6-<1'-phenylseleno-3'-(3'',4'',5''-trimethoxyphenyl)propyl>cyclohepta-2,4,6-trienone

Guidance literature:: With sodium tetrahydroborate; In methanol; Ambient temperature;

Reference yield: 5.0%

: 125730-99-6
(RS)-6-<1'-mesyloxy-3'-(3'',4'',5''-trimethoxyphenyl)propyl>-2-methoxycyclohepta-2,4,6-trienone

: 153870-98-5
deacetamido-12a,12b-secocolchicin

: (RS)-2-methoxy-6-<1'-phenylseleno-3'-(3'',4'',5''-trimethoxyphenyl)propyl>cyclohepta-2,4,6-trienone

Guidance literature:: With sodium tetrahydroborate; diphenyl diselenide; In methanol; Ambient temperature;

Reference yield:

: 1504-56-9
(E)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-ol

: 153870-98-5
deacetamido-12a,12b-secocolchicin

Guidance literature:: Multi-step reaction with 11 steps

1: 75 percent / barium manganate / CH₂Cl₂ / 4 h / Ambient temperature

2: 77 percent / (3aα,5aβ,6aβ,6bα)-6,6-dibromo-2-dimethylhexahydro-3aH-cyclopropa<1,3>benzodioxole / tetrahydrofuran; hexane / 3 h / -100 °C

3: 96 percent / H₂ / 10percent palladium on charcoal / methanol / 1.5 h / 760 Torr

4: DMAP / pyridine / Ambient temperature

5: 90 percent / aq.HCl / tetrahydrofuran / 25 h / Ambient temperature

6: 1.) TFFA, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -60 deg C, 1.5 h, 2.) -60 deg C, 1.5 h

7: 75 percent / K₂CO₃ / acetone / 5 h / Ambient temperature

8: 85 percent / DBU / benzene / 1 h / Ambient temperature

9: 79 percent / K₂CO₃ / methanol / 2.5 h / Ambient temperature

10: Et₃N / CH₂Cl₂ / 0.33 h / 0 - 5 °C

11: 85 percent / NaBH₄ / methanol / Ambient temperature

With hydrogenchloride; dmap; sodium tetrahydroborate; barium manganate; (3aα,5aβ,6aβ,6bα)-6,6-dibromo-2-dimethylhexahydro-3aH-cyclopropa<1,3>benzodioxole; hydrogen; potassium carbonate; dimethyl sulfoxide; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; hexane; dichloromethane; acetone; benzene;