8-[hydroxy(2-methoxyphenyl)pyridin-3-ylmethyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one

Base Information

• Chemical Name: 8-[hydroxy(2-methoxyphenyl)pyridin-3-ylmethyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one
• CAS No.: 1417445-08-9
• Molecular Formula: C₂₄H₂₂N₂O₃
• Molecular Weight: 386.45
• Mol file: 1417445-08-9.mol

Synonyms:8-[hydroxy(2-methoxyphenyl)pyridin-3-ylmethyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one

Chemical Property of 8-[hydroxy(2-methoxyphenyl)pyridin-3-ylmethyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-[hydroxy(2-methoxyphenyl)pyridin-3-ylmethyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one

There total 3 articles about 8-[hydroxy(2-methoxyphenyl)pyridin-3-ylmethyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

8-(pyridin-4-ylcarbonyl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (1194450-10-6) + 2-methoxyphenylmagnesium bromide (16750-63-3) → 8-[hydroxy(2-methoxyphenyl)pyridin-3-ylmethyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (1417445-08-9)

Guidance literature:

In tetrahydrofuran; at -78 - 20 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm301408t

Reference yield:

pyroquilone (57369-32-1,84930-99-4) → 8-[hydroxy(2-methoxyphenyl)pyridin-3-ylmethyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (1417445-08-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / 4 h / 140 °C

2: tetrahydrofuran / 16 h / -78 - 20 °C / Inert atmosphere

With aluminum (III) chloride; In tetrahydrofuran; 1: |Friedel-Crafts Acylation;

DOI:10.1021/jm301408t

Reference yield:

isonicotinoyl chloride hydrochloride (39178-35-3) → 8-[hydroxy(2-methoxyphenyl)pyridin-3-ylmethyl]-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one (1417445-08-9)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / 4 h / 140 °C

2: tetrahydrofuran / 16 h / -78 - 20 °C / Inert atmosphere

With aluminum (III) chloride; In tetrahydrofuran; 1: |Friedel-Crafts Acylation;

DOI:10.1021/jm301408t

upstream raw materials:

8-(pyridin-4-ylcarbonyl)-1,2,5,6-tetrahydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one

2-methoxyphenylmagnesium bromide

pyroquilone

isonicotinoyl chloride hydrochloride

Downstream raw materials:

C₂₄H₂₂N₂O₂