cis-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

Base Information

• Chemical Name: cis-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane
• CAS No.: 267402-73-3
• Molecular Formula: C₂₁H₂₅NO₃
• Molecular Weight: 339.434

Synonyms:cis-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

Chemical Property of cis-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

Chemical Property:

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Technology Process of cis-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

There total 3 articles about cis-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-cyano-4-phenylcyclohexanone (25115-74-6) → cis-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane (267402-73-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / NaBH₄ / tetrahydrofuran / -78 °C

2: LiAlH₄ / tetrahydrofuran / Heating

3: Et₃N / 20 °C

With sodium tetrahydroborate; lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran;

DOI:10.1016/S0960-894X(03)00014-3

Reference yield:

cis-4-hydroxy-1-phenylcyclohexanecarbonitrile (38289-22-4) → cis-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane (267402-73-3)

Guidance literature:

Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / Heating

2: Et₃N / 20 °C

With lithium aluminium tetrahydride; triethylamine; In tetrahydrofuran;

DOI:10.1016/S0960-894X(03)00014-3

Reference yield:

2-Methoxybenzoyl chloride (21615-34-9) + cis-1-hydroxy-4-phenyl-4-(aminomethyl)cyclohexane (267405-16-3) → cis-1-hydroxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane (267402-73-3)

Guidance literature:

With triethylamine; at 20 ℃;

DOI:10.1016/S0960-894X(03)00014-3

upstream raw materials:

2-Methoxybenzoyl chloride

cis-1-hydroxy-4-phenyl-4-(aminomethyl)cyclohexane

4-cyano-4-phenylcyclohexanone

cis-4-hydroxy-1-phenylcyclohexanecarbonitrile

Downstream raw materials:

methanesulfonic acid 4-[(2-methoxy-benzoylamino)-methyl]-4-phenyl-cyclohexyl ester

carbonic acid 4-[(2-methoxy-benzoylamino)-methyl]-4-phenyl-cyclohexyl ester 4-nitro-phenyl ester

cis-1-(t-Butoxycarbonylmethyl)oxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

cis-1-Benzyloxy-4-phenyl-4-(3-(2-methoxyphenyl)-3-oxo-2-azaprop-1-yl)cyclohexane

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