1-[1-(3,5-dimethoxybenzyl)-1H-1,2,3-triazol-4-yl]-2-(2-methoxyphenyl)ethanone

Base Information

• Chemical Name: 1-[1-(3,5-dimethoxybenzyl)-1H-1,2,3-triazol-4-yl]-2-(2-methoxyphenyl)ethanone
• CAS No.: 1357356-71-8
• Molecular Formula: C₂₀H₂₁N₃O₄
• Molecular Weight: 367.404

Synonyms:1-[1-(3,5-dimethoxybenzyl)-1H-1,2,3-triazol-4-yl]-2-(2-methoxyphenyl)ethanone

Chemical Property of 1-[1-(3,5-dimethoxybenzyl)-1H-1,2,3-triazol-4-yl]-2-(2-methoxyphenyl)ethanone

Chemical Property:

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Technology Process of 1-[1-(3,5-dimethoxybenzyl)-1H-1,2,3-triazol-4-yl]-2-(2-methoxyphenyl)ethanone

There total 2 articles about 1-[1-(3,5-dimethoxybenzyl)-1H-1,2,3-triazol-4-yl]-2-(2-methoxyphenyl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

1-(2-methoxyphenyl)-4-(trimethylsilyl)but-3-yn-2-one (1357356-73-0) + 1-(azidomethyl)-3,5-dimethoxybenzene (712329-47-0) → 1-[1-(3,5-dimethoxybenzyl)-1H-1,2,3-triazol-4-yl]-2-(2-methoxyphenyl)ethanone (1357356-71-8)

Guidance literature:

With sodium L-ascorbate; copper dichloride; In water; acetonitrile; at 20 - 80 ℃;

DOI:10.1002/ejoc.201101346

Reference yield:

2-(2-methoxyphenyl)acetyl chloride (28033-63-8) → 1-[1-(3,5-dimethoxybenzyl)-1H-1,2,3-triazol-4-yl]-2-(2-methoxyphenyl)ethanone (1357356-71-8)

Guidance literature:

Multi-step reaction with 2 steps

1: aluminum (III) chloride / dichloromethane / 0 °C

2: sodium L-ascorbate; copper dichloride / water; acetonitrile / 20 - 80 °C

With aluminum (III) chloride; sodium L-ascorbate; copper dichloride; In dichloromethane; water; acetonitrile;

DOI:10.1002/ejoc.201101346

Reference yield: 68.0%

1-[1-(3,5-dimethoxybenzyl)-1H-1,2,3-triazol-4-yl]-2-(2-methoxyphenyl)ethanone (1357356-71-8) → 1-[1-(3,5-dimethoxybenzyl)-1H-1,2,3-triazol-4-yl]-2-(2-methoxyphenyl)ethane-1,2-dione (1357356-88-7)

Guidance literature:

With copper(l) iodide; 2.9-dimethyl-1,10-phenanthroline; In acetonitrile; at 80 ℃;

DOI:10.1002/ejoc.201101346

upstream raw materials:

1-(2-methoxyphenyl)-4-(trimethylsilyl)but-3-yn-2-one

1-(azidomethyl)-3,5-dimethoxybenzene

2-(2-methoxyphenyl)acetyl chloride

Downstream raw materials:

1-[1-(3,5-dimethoxybenzyl)-1H-1,2,3-triazol-4-yl]-2-(2-methoxyphenyl)ethane-1,2-dione

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