ethyl 3-{4-[2-(5-benzoyl-3-formylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate

Base Information

Chemical Name:ethyl 3-{4-[2-(5-benzoyl-3-formylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate
CAS No.:1433195-02-8
Molecular Formula:C₃₁H₃₁NO₆
Molecular Weight:513.59
Hs Code.:

Synonyms:ethyl 3-{4-[2-(5-benzoyl-3-formylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate

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Chemical Property of ethyl 3-{4-[2-(5-benzoyl-3-formylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate

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Technology Process of ethyl 3-{4-[2-(5-benzoyl-3-formylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate

There total 4 articles about ethyl 3-{4-[2-(5-benzoyl-3-formylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 901113-92-6
ethyl 3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-propionate

: 5-benzoyl-1H-indole-3-carboxaldehyde

: 1433195-02-8
ethyl 3-{4-[2-(5-benzoyl-3-formylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate

Guidance literature:: 5-benzoyl-1H-indole-3-carboxaldehyde; With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h;

ethyl 3-[4-(2-chloroethoxy)-phenyl]-2-ethoxy-propionate; In N,N-dimethyl-formamide; for 15h; Reflux;
DOI:10.1002/cmdc.201200316

Reference yield:

: 120-72-9
indole

: 1433195-02-8
ethyl 3-{4-[2-(5-benzoyl-3-formylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere; Cooling with ice

1.2: 0 - 20 °C / Inert atmosphere

2.1: aluminum (III) chloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

3.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

3.2: 15 h / Reflux

With aluminum (III) chloride; oxalyl dichloride; potassium carbonate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201200316

Reference yield:

: 487-89-8,1228547-52-1
Indole-3-carboxaldehyde

: 1433195-02-8
ethyl 3-{4-[2-(5-benzoyl-3-formylindol-1-yl)ethoxy]phenyl}-2-ethoxypropionate

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / 1,2-dichloro-ethane / 20 °C / Inert atmosphere

2.1: potassium carbonate / N,N-dimethyl-formamide / 1 h / 100 °C

2.2: 15 h / Reflux

With aluminum (III) chloride; potassium carbonate; In 1,2-dichloro-ethane; N,N-dimethyl-formamide;
DOI:10.1002/cmdc.201200316