[1-(6-but-3-enyl-2,3,4-trimethoxy-phenyl)-prop-2-ynyloxy]-tert-butyl-dimethyl-silane

Base Information

Chemical Name:[1-(6-but-3-enyl-2,3,4-trimethoxy-phenyl)-prop-2-ynyloxy]-tert-butyl-dimethyl-silane
CAS No.:934749-90-3
Molecular Formula:C₂₂H₃₄O₄Si
Molecular Weight:390.595
Hs Code.:

[1-(6-but-3-enyl-2,3,4-trimethoxy-phenyl)-prop-2-ynyloxy]-<i>tert</i>-butyl-dimethyl-silane

Synonyms:[1-(6-but-3-enyl-2,3,4-trimethoxy-phenyl)-prop-2-ynyloxy]-tert-butyl-dimethyl-silane

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Chemical Property of [1-(6-but-3-enyl-2,3,4-trimethoxy-phenyl)-prop-2-ynyloxy]-tert-butyl-dimethyl-silane

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Technology Process of [1-(6-but-3-enyl-2,3,4-trimethoxy-phenyl)-prop-2-ynyloxy]-tert-butyl-dimethyl-silane

There total 8 articles about [1-(6-but-3-enyl-2,3,4-trimethoxy-phenyl)-prop-2-ynyloxy]-tert-butyl-dimethyl-silane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 934749-99-2
1-but-3-enyl-2-[1-(tert-butyl-dimethyl-silanyloxy)-3-trimethylsilanyl-prop-2-ynyl]-3,4,5-trimethoxy-benzene

: 934749-90-3
[1-(6-but-3-enyl-2,3,4-trimethoxy-phenyl)-prop-2-ynyloxy]-tert-butyl-dimethyl-silane

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃; for 4h;
DOI:10.1021/ol0630548

Reference yield:

: 934749-87-8
3-(2-formyl-3,4,5-trimethoxy-phenyl)-propionic acid methyl ester

: 934749-90-3
[1-(6-but-3-enyl-2,3,4-trimethoxy-phenyl)-prop-2-ynyloxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 0.25 h / -70 °C

1.2: 2.09 g / tetrahydrofuran; hexane / 1.5 h / -70 °C

2.1: 83 percent / imidazole / dimethylformamide / 18 h / 20 °C

3.1: 2.17 g / LiAlH₄ / tetrahydrofuran / 0.5 h / -10 °C

4.1: 68 percent / PDC / CH₂Cl₂ / 18 h / 20 °C

5.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / 20 °C

5.2: 1.6 g / tetrahydrofuran; hexane / 0.5 h / 15 - 20 °C

6.1: 86 percent / K₂CO₃ / methanol / 4 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; potassium carbonate; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; 5.2: Wittig reaction;
DOI:10.1021/ol0630548

Reference yield:

: 934749-97-0
3-[2-(1-hydroxy-3-trimethylsilanyl-prop-2-ynyl)-3,4,5-trimethoxy-phenyl]-propionic acid methyl ester

: 934749-90-3
[1-(6-but-3-enyl-2,3,4-trimethoxy-phenyl)-prop-2-ynyloxy]-tert-butyl-dimethyl-silane

Guidance literature:: Multi-step reaction with 5 steps

1.1: 83 percent / imidazole / dimethylformamide / 18 h / 20 °C

2.1: 2.17 g / LiAlH₄ / tetrahydrofuran / 0.5 h / -10 °C

3.1: 68 percent / PDC / CH₂Cl₂ / 18 h / 20 °C

4.1: n-butyllithium / tetrahydrofuran; hexane / 0.75 h / 20 °C

4.2: 1.6 g / tetrahydrofuran; hexane / 0.5 h / 15 - 20 °C

5.1: 86 percent / K₂CO₃ / methanol / 4 h / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; dipyridinium dichromate; n-butyllithium; potassium carbonate; In tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; 4.2: Wittig reaction;
DOI:10.1021/ol0630548