trans-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexanamine

Base Information

Chemical Name:trans-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexanamine
CAS No.:1388890-58-1
Molecular Formula:C₁₅H₁₉N₃OS
Molecular Weight:289.401
Hs Code.:

Synonyms:trans-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexanamine

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Chemical Property of trans-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexanamine

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Technology Process of trans-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexanamine

There total 5 articles about trans-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 1388890-61-6
2-[trans-4-(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)hydroxycyclohexyl]isoindoline-1,3-dione

: 1388890-58-1
trans-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexanamine

Guidance literature:: With hydrazine hydrate; In ethanol; at 20 ℃; Reflux;

Reference yield:

: 1388891-81-3
tert-butyl N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yloxy]cyclohexyl)carbamate

: 1388890-58-1
trans-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexanamine

Guidance literature:: tert-butyl N-(4-[7-thia-9,11-diazatricyclo[6.4.0.0(2,6)]dodeca-1⁽⁸⁾,2⁽⁶⁾,9,11-tetraen-12-yloxy]cyclohexyl)carbamate; With hydrogenchloride; In dichloromethane; at 0 - 20 ℃;

With sodium carbonate; In dichloromethane; water; pH=8 - 9;

Reference yield:

: 300816-22-2
4-chloro-6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidine

: 1388890-58-1
trans-4-[(6,7-dihydro-5H-cyclopenta[4,5]thieno[2,3-d]pyrimidin-4-yl)oxy]cyclohexanamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 - 20 °C / Inert atmosphere

1.2: 5 h / 20 °C / Inert atmosphere

2.1: hydrogenchloride / dichloromethane / 0 - 20 °C

2.2: pH 8 - 9

With hydrogenchloride; sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;