4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazole

Base Information

• Chemical Name: 4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazole
• CAS No.: 1027335-43-8
• Molecular Formula: C₁₃H₁₇N₃
• Molecular Weight: 215.298
• Mol file: 1027335-43-8.mol

Synonyms:4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazole

Chemical Property of 4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazole

There total 1 articles about 4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

ortho-methylphenyl iodide (615-37-2) + hex-1-yne (693-02-7) → 4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazole (1027335-43-8)

Guidance literature:

With copper(l) iodide; sodium azide; sodium L-ascorbate; N,N`-dimethylethylenediamine; In water; dimethyl sulfoxide; at 20 ℃; Inert atmosphere;

DOI:10.1021/ol800773x

Reference yield: 96.0%

4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazole (1027335-43-8) + methyl 3-chlorobenzoate (2905-65-9) → 3-(5-butyl-3-o-tolyl-3H-1,2,3-triazol-4-yl)-benzoic acid methyl ester (1111662-52-2)

Guidance literature:

With palladium diacetate; potassium carbonate; tricyclohexylphosphine; In toluene; at 120 ℃; for 22h; regioselective reaction; Inert atmosphere;

DOI:10.1002/adsc.200800016

Reference yield: 95.0%

ethyl 5-bromofuran-2-carboxylate (6132-37-2) + 4-n-butyl-1-(2-tolyl)-1H-1,2,3-triazole (1027335-43-8) → 5-(2-(4-n-butyl-1H-1,2,3-triazol-1-yl)-3-methylphenyl)furan-2-carboxylic acid ethyl ester (1027335-54-1)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; mesitylenecarboxylic acid; potassium carbonate; In toluene; at 120 ℃; for 19h; chemoselective reaction; Inert atmosphere;

DOI:10.1021/ol800773x

upstream raw materials:

ortho-methylphenyl iodide

hex-1-yne

Downstream raw materials:

1-(4-(4-butyl-1-o-tolyl-1H-1,2,3-triazol-5-yl)phenyl)-2,2-dimethylpropan-1-one

4-butyl-5-(4-methoxyphenyl)-1-o-tolyl-1H-1,2,3-triazole

[3-(5-butyl-3-o-tolyl-3H-1,2,3-triazol-4-yl)-phenyl]-phenylmethanone

4-butyl-1-o-tolyl-5-p-tolyl-1H-1,2,3-triazole