(R)-4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)pyrimidine-2-carboxamide

Base Information

Chemical Name:(R)-4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)pyrimidine-2-carboxamide
CAS No.:1437034-33-7
Molecular Formula:C₁₉H₁₆FN₃O₄
Molecular Weight:369.352
Hs Code.:

Synonyms:(R)-4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)pyrimidine-2-carboxamide

Suppliers and Price of (R)-4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)pyrimidine-2-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)pyrimidine-2-carboxamide

Chemical Property:

Purity/Quality:

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Technology Process of (R)-4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)pyrimidine-2-carboxamide

There total 7 articles about (R)-4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)pyrimidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 684220-30-2
4,6-dichloropyrimidine-2-carboxylic acid

: 1437034-33-7
(R)-4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)pyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: caesium carbonate; bis-triphenylphosphine-palladium(II) chloride / ethanol; water; 1,2-dimethoxyethane / 3 h / 60 °C / Sealed tube

2: hydrogenchloride / 1,4-dioxane / 12 h / 20 °C

3: bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 70 °C / Sealed tube

4: AD-mix β; water / isopropyl alcohol / 12 h / 0 °C

5: hydrogenchloride / 1,4-dioxane / 12 h / 20 °C

6: ammonia / methanol / 12 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; AD-mix β; tetrabutyl ammonium fluoride; ammonia; water; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; 1,2-dimethoxyethane; ethanol; water; isopropyl alcohol;

Reference yield:

: 1437034-84-8
C₂₀H₁₇FN₂O₅

: 1437034-33-7
(R)-4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)pyrimidine-2-carboxamide

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 12h;

Reference yield:

: 1426337-43-0
C₁₇H₁₀ClFN₂O₃

: 1437034-33-7
(R)-4-(1,2-dihydroxyethyl)-6-(4-(4-fluorophenoxy)phenyl)pyrimidine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride / 1,4-dioxane / 12 h / 20 °C

2: bis-triphenylphosphine-palladium(II) chloride; tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 70 °C / Sealed tube

3: AD-mix β; water / isopropyl alcohol / 12 h / 0 °C

4: hydrogenchloride / 1,4-dioxane / 12 h / 20 °C

5: ammonia / methanol / 12 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; AD-mix β; tetrabutyl ammonium fluoride; ammonia; water; In tetrahydrofuran; 1,4-dioxane; methanol; isopropyl alcohol;