2,2-dimethyl-propionic acid 3-(3,4-dimethoxy-benzyl)-8b-hydroxy-2,6-dioxo-7-(toluene-4-sulfonyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-8-triisopropylsilanyloxymethyl-1,2,3,5,5a,6,7,8,8a,8b-decahydro-imidazo[4,5-e]isoindol-5-ylmethyl ester

Base Information

Chemical Name:2,2-dimethyl-propionic acid 3-(3,4-dimethoxy-benzyl)-8b-hydroxy-2,6-dioxo-7-(toluene-4-sulfonyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-8-triisopropylsilanyloxymethyl-1,2,3,5,5a,6,7,8,8a,8b-decahydro-imidazo[4,5-e]isoindol-5-ylmethyl ester
CAS No.:896141-08-5
Molecular Formula:C₅₀H₆₉N₃O₁₂S₂Si
Molecular Weight:996.328
Hs Code.:

2,2-dimethyl-propionic acid 3-(3,4-dimethoxy-benzyl)-8b-hydroxy-2,6-dioxo-7-(toluene-4-sulfonyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-8-triisopropylsilanyloxymethyl-1,2,3,5,5a,6,7,8,8a,8b-decahydro-imidazo[4,5-<i>e</i>]isoindol-5-ylmethyl ester

Synonyms:2,2-dimethyl-propionic acid 3-(3,4-dimethoxy-benzyl)-8b-hydroxy-2,6-dioxo-7-(toluene-4-sulfonyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-8-triisopropylsilanyloxymethyl-1,2,3,5,5a,6,7,8,8a,8b-decahydro-imidazo[4,5-e]isoindol-5-ylmethyl ester

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Chemical Property of 2,2-dimethyl-propionic acid 3-(3,4-dimethoxy-benzyl)-8b-hydroxy-2,6-dioxo-7-(toluene-4-sulfonyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-8-triisopropylsilanyloxymethyl-1,2,3,5,5a,6,7,8,8a,8b-decahydro-imidazo[4,5-e]isoindol-5-ylmethyl ester

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Technology Process of 2,2-dimethyl-propionic acid 3-(3,4-dimethoxy-benzyl)-8b-hydroxy-2,6-dioxo-7-(toluene-4-sulfonyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-8-triisopropylsilanyloxymethyl-1,2,3,5,5a,6,7,8,8a,8b-decahydro-imidazo[4,5-e]isoindol-5-ylmethyl ester

There total 10 articles about 2,2-dimethyl-propionic acid 3-(3,4-dimethoxy-benzyl)-8b-hydroxy-2,6-dioxo-7-(toluene-4-sulfonyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-8-triisopropylsilanyloxymethyl-1,2,3,5,5a,6,7,8,8a,8b-decahydro-imidazo[4,5-e]isoindol-5-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 17342-08-4
(S)-Pyroglutaminol

: 896141-08-5
2,2-dimethyl-propionic acid 3-(3,4-dimethoxy-benzyl)-8b-hydroxy-2,6-dioxo-7-(toluene-4-sulfonyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-8-triisopropylsilanyloxymethyl-1,2,3,5,5a,6,7,8,8a,8b-decahydro-imidazo[4,5-e]isoindol-5-ylmethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: 66 percent / imidazole / dimethylformamide

2.1: 90 percent / NaHMDS / tetrahydrofuran

3.1: LiHMDS / tetrahydrofuran / -78 °C

3.2: tetrahydrofuran / -78 °C

3.3: 74 percent / H₂O₂ / ethyl acetate / 0 °C

4.1: 2,6-lutidine / benzene / 1 h / 160 °C / microwave irradiation

5.1: 97 percent / triethylamine / CH₂Cl₂

6.1: dimethyldioxirane; magnesium sulfate / acetone; CH₂Cl₂ / 2 h / -60 °C

With 1H-imidazole; 2,6-dimethylpyridine; sodium hexamethyldisilazane; 3,3-dimethyldioxirane; magnesium sulfate; triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone; benzene; 4.1: Diels-Alder reaction;
DOI:10.1016/j.tet.2005.12.068

Reference yield:

: 896141-06-3
2,2-Dimethyl-propionic acid (5R,5aS,8S,8aS)-3-(3,4-dimethoxy-benzyl)-2,6-dioxo-7-(toluene-4-sulfonyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-8-triisopropylsilanyloxymethyl-1,2,3,4,5,5a,6,7,8,8a-decahydro-imidazo[4,5-e]isoindol-5-ylmethyl ester

: 896141-08-5
2,2-dimethyl-propionic acid 3-(3,4-dimethoxy-benzyl)-8b-hydroxy-2,6-dioxo-7-(toluene-4-sulfonyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-8-triisopropylsilanyloxymethyl-1,2,3,5,5a,6,7,8,8a,8b-decahydro-imidazo[4,5-e]isoindol-5-ylmethyl ester

Guidance literature:: With 3,3-dimethyldioxirane; magnesium sulfate; In dichloromethane; acetone; at -60 ℃; for 2h;
DOI:10.1016/j.tet.2005.12.068

Reference yield:

: 852615-09-9
(5R,5aS,8S,8aS)-3-(3,4-Dimethoxy-benzyl)-5-hydroxymethyl-7-(toluene-4-sulfonyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-8-triisopropylsilanyloxymethyl-1,3,4,5,5a,7,8,8a-octahydro-imidazo[4,5-e]isoindole-2,6-dione

: 896141-08-5
2,2-dimethyl-propionic acid 3-(3,4-dimethoxy-benzyl)-8b-hydroxy-2,6-dioxo-7-(toluene-4-sulfonyl)-1-[2-(toluene-4-sulfonyl)-ethyl]-8-triisopropylsilanyloxymethyl-1,2,3,5,5a,6,7,8,8a,8b-decahydro-imidazo[4,5-e]isoindol-5-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / triethylamine / CH₂Cl₂

2: dimethyldioxirane; magnesium sulfate / acetone; CH₂Cl₂ / 2 h / -60 °C

With 3,3-dimethyldioxirane; magnesium sulfate; triethylamine; In dichloromethane; acetone;
DOI:10.1016/j.tet.2005.12.068