N-allyl-2-bromo-4,5-dimethoxy-N-((1R,5S)-2-methylene-5-(prop-1-en-2-yl)cyclohexyl)benzene sulfonamide

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Chemical Name:N-allyl-2-bromo-4,5-dimethoxy-N-((1R,5S)-2-methylene-5-(prop-1-en-2-yl)cyclohexyl)benzene sulfonamide
CAS No.:1427435-78-6
Molecular Formula:C₂₁H₂₈BrNO₄S
Molecular Weight:470.428
Hs Code.:

Synonyms:N-allyl-2-bromo-4,5-dimethoxy-N-((1R,5S)-2-methylene-5-(prop-1-en-2-yl)cyclohexyl)benzene sulfonamide

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Chemical Property of N-allyl-2-bromo-4,5-dimethoxy-N-((1R,5S)-2-methylene-5-(prop-1-en-2-yl)cyclohexyl)benzene sulfonamide

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Technology Process of N-allyl-2-bromo-4,5-dimethoxy-N-((1R,5S)-2-methylene-5-(prop-1-en-2-yl)cyclohexyl)benzene sulfonamide

There total 3 articles about N-allyl-2-bromo-4,5-dimethoxy-N-((1R,5S)-2-methylene-5-(prop-1-en-2-yl)cyclohexyl)benzene sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1427435-77-5
2-bromo-4,5-dimethoxy-N-((1R,5S)-2-methylene-5-(prop-1-en-2-yl)cyclohexyl)benzene sulfonamide

: 106-95-6
allyl bromide

: 1427435-78-6
N-allyl-2-bromo-4,5-dimethoxy-N-((1R,5S)-2-methylene-5-(prop-1-en-2-yl)cyclohexyl)benzene sulfonamide

Guidance literature:: 2-bromo-4,5-dimethoxy-N-((1R,5S)-2-methylene-5-(prop-1-en-2-yl)cyclohexyl)benzene sulfonamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 ℃; for 0.5h;

allyl bromide; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 15h;
DOI:10.1021/jo4000306

Reference yield:

: 2,2,2-trichloro-N-((5S)-2-methylene-5-(prop-1-en-2-yl)cyclohexyl)acetamide

: 1427435-78-6
N-allyl-2-bromo-4,5-dimethoxy-N-((1R,5S)-2-methylene-5-(prop-1-en-2-yl)cyclohexyl)benzene sulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydroxide / dichloromethane; ethanol; water / 15 h / 50 °C

2.1: triethylamine / dichloromethane / 5 h / 0 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

3.2: 15 h / 0 - 20 °C

With sodium hydride; triethylamine; sodium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo4000306

Reference yield:

: C₁₀H₁₇N

: 1427435-78-6
N-allyl-2-bromo-4,5-dimethoxy-N-((1R,5S)-2-methylene-5-(prop-1-en-2-yl)cyclohexyl)benzene sulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 5 h / 0 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C

2.2: 15 h / 0 - 20 °C

With sodium hydride; triethylamine; In dichloromethane; N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jo4000306