(2R,3R)-3-Methylamino-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester

Base Information

Chemical Name:(2R,3R)-3-Methylamino-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester
CAS No.:859235-92-0
Molecular Formula:C₁₅H₂₂N₂O₄
Molecular Weight:294.351
Hs Code.:

Synonyms:(2R,3R)-3-Methylamino-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester

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Chemical Property of (2R,3R)-3-Methylamino-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester

Chemical Property:

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Technology Process of (2R,3R)-3-Methylamino-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester

There total 12 articles about (2R,3R)-3-Methylamino-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 859235-80-6
(2R,3R)-3-[(9H-Fluoren-9-ylmethoxycarbonyl)-methyl-amino]-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester

: 859235-92-0
(2R,3R)-3-Methylamino-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester

Guidance literature:: With diethylamine; In acetonitrile; at 20 ℃; for 0.666667h;
DOI:10.1002/chem.200400977

Reference yield:

: (2R,3R)-2-Amino-3-(benzyloxycarbonyl-methyl-amino)-butyric acid methyl ester

: 859235-92-0
(2R,3R)-3-Methylamino-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 0.135 g / tetrahydrofuran / 24 h / 20 °C

2: 100 percent / H₂ / Pd/C / ethyl acetate / 3 h / 20 °C

3: 0.135 g / 2,4,6-trimethylpyridine; 7-aza-1-hydroxybenzotriazole / ethyl acetate / 15 h / 20 °C

4: aq. HCl / ethyl acetate / 3 h / 20 °C

5: 0.122 g / 2,4,6-trimethylpyridine; i-Pr₂NEt / acetonitrile / 16 h / 20 °C

6: Et₂NH / acetonitrile / 0.67 h / 20 °C

With 2,4,6-trimethyl-pyridine; hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; hydrogen; diethylamine; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; ethyl acetate; acetonitrile;
DOI:10.1002/chem.200400977

Reference yield:

: 859235-83-9
methyl (2S,3R)-3-(benzyloxycarbonyl-N-methylamino)-2-hydroxybutyrate

: 859235-92-0
(2R,3R)-3-Methylamino-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester

Guidance literature:: Multi-step reaction with 9 steps

1: Et₃N / CH₂Cl₂ / 5 h / -30 - 20 °C

2: 0.191 g / NaN₃ / dimethylformamide / 15 h / 70 °C

3: PPh₃; H₂O / tetrahydrofuran / 24 h / 20 °C

4: 0.135 g / tetrahydrofuran / 24 h / 20 °C

5: 100 percent / H₂ / Pd/C / ethyl acetate / 3 h / 20 °C

6: 0.135 g / 2,4,6-trimethylpyridine; 7-aza-1-hydroxybenzotriazole / ethyl acetate / 15 h / 20 °C

7: aq. HCl / ethyl acetate / 3 h / 20 °C

8: 0.122 g / 2,4,6-trimethylpyridine; i-Pr₂NEt / acetonitrile / 16 h / 20 °C

9: Et₂NH / acetonitrile / 0.67 h / 20 °C

With 2,4,6-trimethyl-pyridine; hydrogenchloride; sodium azide; 1-hydroxy-7-aza-benzotriazole; water; hydrogen; diethylamine; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/chem.200400977