(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(benzyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(benzyl)amino)ethoxy)-3-chloroindazole-1-carboxylate
CAS No.:1221235-90-0
Molecular Formula:C₂₉H₃₂Cl₂N₄O₄
Molecular Weight:571.503
Hs Code.:

Synonyms:(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(benzyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

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Chemical Property of (R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(benzyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

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Technology Process of (R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(benzyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

There total 10 articles about (R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(benzyl)amino)ethoxy)-3-chloroindazole-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1221235-89-7
(R)-tert-butyl 6-(2-(benzyl(2-(4-chloro-3-nitrophenyl)-2-hydroxyethyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

: 1221235-90-0
(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(benzyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

Guidance literature:: With hydrogen; CM-101 catalyst; In tetrahydrofuran; methanol; at 20 ℃;

Reference yield:

: 6967-12-0
6-amino-1H-indazole

: 1221235-90-0
(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(benzyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

Guidance literature:: Multi-step reaction with 10 steps

1.1: sodium nitrite; tetrafluoroboric acid / water / 0.67 h / 0 °C

1.2: 0.5 h / 50 - 130 °C

2.1: sodium hydroxide; water / ethanol / 1 h / 20 °C

2.2: pH ~ 7

3.1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

4.1: N-chloro-succinimide; potassium tert-butylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

5.1: triethylamine / dmap / tetrahydrofuran / 20 °C

6.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

7.1: triphenylphosphine; diamide / tetrahydrofuran / 20 °C

8.1: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / ethanol; water; methanol / 1.17 h / 20 °C / Inert atmosphere

9.1: isopropyl alcohol / Reflux

10.1: hydrogen / CM-101 / tetrahydrofuran; methanol / 20 °C

With 1H-imidazole; hydrogenchloride; N-chloro-succinimide; tetrafluoroboric acid; diamide; potassium tert-butylate; tetrabutyl ammonium fluoride; water; hydrogen; triethylamine; triphenylphosphine; sodium hydroxide; sodium nitrite; dmap; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 23244-88-4
1H-indazol-6-ol

: 1221235-90-0
(R)-tert-butyl 6-(2-((2-(3-amino-4-chlorophenyl)-2-hydroxyethyl)(benzyl)amino)ethoxy)-3-chloroindazole-1-carboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: 1H-imidazole / N,N-dimethyl-formamide / 20 °C

2: N-chloro-succinimide; potassium tert-butylate / tetrahydrofuran / 4 h / 0 - 20 °C / Inert atmosphere

3: triethylamine / dmap / tetrahydrofuran / 20 °C

4: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

5: triphenylphosphine; diamide / tetrahydrofuran / 20 °C

6: hydrogenchloride; hydrogen / 5%-palladium/activated carbon / ethanol; water; methanol / 1.17 h / 20 °C / Inert atmosphere

7: isopropyl alcohol / Reflux

8: hydrogen / CM-101 / tetrahydrofuran; methanol / 20 °C

With 1H-imidazole; hydrogenchloride; N-chloro-succinimide; diamide; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; triethylamine; triphenylphosphine; dmap; 5%-palladium/activated carbon; In tetrahydrofuran; methanol; ethanol; water; N,N-dimethyl-formamide; isopropyl alcohol;