2-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)but-3-yn-2-ol

Base Information

Chemical Name:2-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)but-3-yn-2-ol
CAS No.:1105663-20-4
Molecular Formula:C₁₇H₂₃BO₃
Molecular Weight:286.179
Hs Code.:

Synonyms:2-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)but-3-yn-2-ol

Suppliers and Price of 2-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)but-3-yn-2-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 2-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)but-3-yn-2-ol

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

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Technology Process of 2-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)but-3-yn-2-ol

There total 2 articles about 2-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)but-3-yn-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 115-19-5
2-methyl-but-3-yn-2-ol

: 73852-88-7
2-(4-iodophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1105663-20-4
2-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)but-3-yn-2-ol

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 80 ℃; Inert atmosphere; Schlenk technique;
DOI:10.1021/jacs.9b13818

Reference yield:

: 115-19-5
2-methyl-but-3-yn-2-ol

: 68716-49-4
p-bromophenylboronic acid pinacol ester

: 1105663-20-4
2-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)but-3-yn-2-ol

Guidance literature:: With copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride; In N,N-dimethyl-formamide; at 110 ℃; for 0.333333h;

Reference yield: 35.0%

: 1458-98-6
2-methyl-3-bromo-1-propene

: 1105663-20-4
2-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)but-3-yn-2-ol

: 4,4,5,5-tetramethyl-2-(4-(3-methyl-3-((2-methylallyl)oxy)but-1-yn-1-yl)phenyl)-1,3,2-dioxaborolane

Guidance literature:: 2-methyl-4-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)but-3-yn-2-ol; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

2-methyl-3-bromo-1-propene; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere; Schlenk technique;
DOI:10.1021/jacs.9b13818