(S)-2-[(R)-2-(2-Benzyloxycarbonyl-acetylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-6-benzyloxycarbonylamino-hexanoic acid methyl ester

Base Information

Chemical Name:(S)-2-[(R)-2-(2-Benzyloxycarbonyl-acetylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-6-benzyloxycarbonylamino-hexanoic acid methyl ester
CAS No.:1026922-59-7
Molecular Formula:C₃₇H₄₂N₄O₈
Molecular Weight:670.762
Hs Code.:

Synonyms:(S)-2-[(R)-2-(2-Benzyloxycarbonyl-acetylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-6-benzyloxycarbonylamino-hexanoic acid methyl ester

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Chemical Property of (S)-2-[(R)-2-(2-Benzyloxycarbonyl-acetylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-6-benzyloxycarbonylamino-hexanoic acid methyl ester

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Technology Process of (S)-2-[(R)-2-(2-Benzyloxycarbonyl-acetylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-6-benzyloxycarbonylamino-hexanoic acid methyl ester

There total 4 articles about (S)-2-[(R)-2-(2-Benzyloxycarbonyl-acetylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-6-benzyloxycarbonylamino-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 40204-26-0
malonic acid monobenzyl ester

: (S)-2-[(R)-2-Amino-3-(1H-indol-3-yl)-2-methyl-propionylamino]-6-benzyloxycarbonylamino-hexanoic acid methyl ester; compound with trifluoro-acetic acid

: 1026922-59-7
(S)-2-[(R)-2-(2-Benzyloxycarbonyl-acetylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-6-benzyloxycarbonylamino-hexanoic acid methyl ester

Guidance literature:: With triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/jm9603072

Reference yield:

: 24498-31-5
(S)-methyl 2-amino-6-(benzyloxycarbonylamino)hexanoate

: 1026922-59-7
(S)-2-[(R)-2-(2-Benzyloxycarbonyl-acetylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-6-benzyloxycarbonylamino-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) DIEA, (benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, 2.) DIEA / 1.) DMF, 0 deg C, 30 min, 2.) DMF, RT, overnight

2: 100 percent / anisole / CH₂Cl₂ / 3 h / 0 - 20 °C

3: 93 percent / DCC, Et₃N / CH₂Cl₂ / 1 h / 0 °C

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; methoxybenzene; triethylamine; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/jm9603072

Reference yield:

: 187395-77-3
(S)-6-Benzyloxycarbonylamino-2-[(R)-2-tert-butoxycarbonylamino-3-(1H-indol-3-yl)-2-methyl-propionylamino]-hexanoic acid methyl ester

: 1026922-59-7
(S)-2-[(R)-2-(2-Benzyloxycarbonyl-acetylamino)-3-(1H-indol-3-yl)-2-methyl-propionylamino]-6-benzyloxycarbonylamino-hexanoic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 100 percent / anisole / CH₂Cl₂ / 3 h / 0 - 20 °C

2: 93 percent / DCC, Et₃N / CH₂Cl₂ / 1 h / 0 °C

With methoxybenzene; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;
DOI:10.1021/jm9603072