5-(2-azidoethyl)-5-benzoyloxymethyl-N-(4-methoxycarbonyl-2-(3-pentylamino)phenyl)pyrrolidin-2-one

Base Information

Chemical Name:5-(2-azidoethyl)-5-benzoyloxymethyl-N-(4-methoxycarbonyl-2-(3-pentylamino)phenyl)pyrrolidin-2-one
CAS No.:623162-16-3
Molecular Formula:C₂₇H₃₃N₅O₅
Molecular Weight:507.59
Hs Code.:

Synonyms:5-(2-azidoethyl)-5-benzoyloxymethyl-N-(4-methoxycarbonyl-2-(3-pentylamino)phenyl)pyrrolidin-2-one

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Chemical Property of 5-(2-azidoethyl)-5-benzoyloxymethyl-N-(4-methoxycarbonyl-2-(3-pentylamino)phenyl)pyrrolidin-2-one

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Technology Process of 5-(2-azidoethyl)-5-benzoyloxymethyl-N-(4-methoxycarbonyl-2-(3-pentylamino)phenyl)pyrrolidin-2-one

There total 9 articles about 5-(2-azidoethyl)-5-benzoyloxymethyl-N-(4-methoxycarbonyl-2-(3-pentylamino)phenyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 619-45-4
4-methoxycarbonyl aniline

: 623162-16-3
5-(2-azidoethyl)-5-benzoyloxymethyl-N-(4-methoxycarbonyl-2-(3-pentylamino)phenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 11 steps

1: 86 percent / 15 h / 112 °C

2: 80 percent / NaH / dimethylformamide / 36 h / 20 °C

3: 84 percent / Na; MeOH / 1 h / 0 °C

4: 67 percent / lithium diisopropylamide / tetrahydrofuran / 4 h / -70 - -60 °C

5: 87 percent / [NO₂]BF₄ / CH₂Cl₂ / 16 h / 0 - 20 °C

6: 81 percent / NaBH₄ / methanol; tetrahydrofuran / 4 h / 0 - 5 °C

7: 77 percent / p-toluenesulfonic acid / 24 h / 20 °C

8: 72.3 percent / N-bromosuccinimide / benzene / 26 h / 20 °C

9: 85 percent / NaN₃ / dimethylformamide / 16 h / 70 - 75 °C

10: 86 percent / aq. Na₂S₂O₇ / tetrahydrofuran / 25 h / 20 °C

11: 70 mg / sodium cyanoborohydride; AcOH / 1,2-dichloro-ethane / 35 h

With methanol; sodium tetrahydroborate; N-Bromosuccinimide; sodium azide; nitronium tetrafluoborate; sodium pyrosulfate; sodium; sodium hydride; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0968-0896(03)00271-2

Reference yield:

: 221382-03-2
diethyl 2-[4-(methoxycarbonyl)phenylamino]malonate

: 623162-16-3
5-(2-azidoethyl)-5-benzoyloxymethyl-N-(4-methoxycarbonyl-2-(3-pentylamino)phenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 10 steps

1: 80 percent / NaH / dimethylformamide / 36 h / 20 °C

2: 84 percent / Na; MeOH / 1 h / 0 °C

3: 67 percent / lithium diisopropylamide / tetrahydrofuran / 4 h / -70 - -60 °C

4: 87 percent / [NO₂]BF₄ / CH₂Cl₂ / 16 h / 0 - 20 °C

5: 81 percent / NaBH₄ / methanol; tetrahydrofuran / 4 h / 0 - 5 °C

6: 77 percent / p-toluenesulfonic acid / 24 h / 20 °C

7: 72.3 percent / N-bromosuccinimide / benzene / 26 h / 20 °C

8: 85 percent / NaN₃ / dimethylformamide / 16 h / 70 - 75 °C

9: 86 percent / aq. Na₂S₂O₇ / tetrahydrofuran / 25 h / 20 °C

10: 70 mg / sodium cyanoborohydride; AcOH / 1,2-dichloro-ethane / 35 h

With methanol; sodium tetrahydroborate; N-Bromosuccinimide; sodium azide; nitronium tetrafluoborate; sodium pyrosulfate; sodium; sodium hydride; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0968-0896(03)00271-2

Reference yield:

: 221382-41-8
spiro 2-(γ-butyrolactone)-5-[N-(4-methoxycarbonylphenyl)pyrrolidin-2-one]

: 623162-16-3
5-(2-azidoethyl)-5-benzoyloxymethyl-N-(4-methoxycarbonyl-2-(3-pentylamino)phenyl)pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: 87 percent / [NO₂]BF₄ / CH₂Cl₂ / 16 h / 0 - 20 °C

2: 81 percent / NaBH₄ / methanol; tetrahydrofuran / 4 h / 0 - 5 °C

3: 77 percent / p-toluenesulfonic acid / 24 h / 20 °C

4: 72.3 percent / N-bromosuccinimide / benzene / 26 h / 20 °C

5: 85 percent / NaN₃ / dimethylformamide / 16 h / 70 - 75 °C

6: 86 percent / aq. Na₂S₂O₇ / tetrahydrofuran / 25 h / 20 °C

7: 70 mg / sodium cyanoborohydride; AcOH / 1,2-dichloro-ethane / 35 h

With sodium tetrahydroborate; N-Bromosuccinimide; sodium azide; nitronium tetrafluoborate; sodium pyrosulfate; sodium cyanoborohydride; toluene-4-sulfonic acid; acetic acid; In tetrahydrofuran; methanol; dichloromethane; 1,2-dichloro-ethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0968-0896(03)00271-2