C₂₂H₂₂N₂O₂

Base Information

Chemical Name:C₂₂H₂₂N₂O₂
CAS No.:1423167-13-8
Molecular Formula:C₂₂H₂₂N₂O₂
Molecular Weight:346.429
Hs Code.:

C<sub>22</sub>H<sub>22</sub>N<sub>2</sub>O<sub>2</sub>

Synonyms:C₂₂H₂₂N₂O₂

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Chemical Property of C₂₂H₂₂N₂O₂

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Technology Process of C₂₂H₂₂N₂O₂

There total 5 articles about C₂₂H₂₂N₂O₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1423167-40-1
tert-butyl 4-((2-(3-methoxybiphenyl-4-yl)acetamido)methyl)benzylcarbamate

: 1423167-13-8
C₂₂H₂₂N₂O₂

Guidance literature:: With boron tribromide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jm301127x

Reference yield:

: 10406-25-4
4-aminobenzyl cyanide

: 1423167-13-8
C₂₂H₂₂N₂O₂

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine / dichloromethane / 16 h / 0 - 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 49 h / 0 - 20 °C / Inert atmosphere

2.2: 0.25 h / 0 °C / Inert atmosphere

3.1: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

4.1: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; lithium aluminium tetrahydride; boron tribromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm301127x

Reference yield:

: 1026089-09-7
2-(4-bromo-2-methoxyphenyl)acetic acid

: 1423167-13-8
C₂₂H₂₂N₂O₂

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; sodium carbonate; tetrabutylammomium bromide / water / 120 °C / Microwave irradiation; Inert atmosphere

2: 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 24 h / 0 - 20 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 0 - 20 °C / Inert atmosphere

With 4-methyl-morpholine; tetrabutylammomium bromide; palladium diacetate; boron tribromide; sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; water; 1: |Suzuki Coupling;
DOI:10.1021/jm301127x