(R)-3-(3'-phenylpropanoyl)-4-iso-propyl-6,6-dimethyl-(1,3)-oxazinan-2-one

Base Information

Chemical Name:(R)-3-(3'-phenylpropanoyl)-4-iso-propyl-6,6-dimethyl-(1,3)-oxazinan-2-one
CAS No.:908290-75-5
Molecular Formula:C₁₈H₂₅NO₃
Molecular Weight:303.401
Hs Code.:

Synonyms:(R)-3-(3'-phenylpropanoyl)-4-iso-propyl-6,6-dimethyl-(1,3)-oxazinan-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-3-(3'-phenylpropanoyl)-4-iso-propyl-6,6-dimethyl-(1,3)-oxazinan-2-one

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Technology Process of (R)-3-(3'-phenylpropanoyl)-4-iso-propyl-6,6-dimethyl-(1,3)-oxazinan-2-one

There total 14 articles about (R)-3-(3'-phenylpropanoyl)-4-iso-propyl-6,6-dimethyl-(1,3)-oxazinan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 36.0%

: 908290-56-2
(R)-4-iso-propyl-6,6-dimethyl-(1,3)-oxazinan-2-one

: 645-45-4
hydrocinnamic acid chloride

: 908290-75-5
(R)-3-(3'-phenylpropanoyl)-4-iso-propyl-6,6-dimethyl-(1,3)-oxazinan-2-one

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 - 20 ℃; for 12h;
DOI:10.1039/b604073j

Reference yield:

: 908290-44-8
tert-butyl (3R,αS)-3-(N-benzyl-N-α-methylbenzylamino)-4-methylpentanoate

: 908290-75-5
(R)-3-(3'-phenylpropanoyl)-4-iso-propyl-6,6-dimethyl-(1,3)-oxazinan-2-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: HCl / 2 h

2.1: H₂ / Pd(OH)2/C / methanol / 3800.26 Torr

3.1: CeCl₃ / tetrahydrofuran / 4 h / 20 °C

3.2: 57 percent / tetrahydrofuran; diethyl ether / 10 h

4.1: 36 percent / LiHMDS / tetrahydrofuran / 12 h / -78 - 20 °C

With hydrogenchloride; cerium(III) chloride; hydrogen; lithium hexamethyldisilazane; palladium dihydroxide; In tetrahydrofuran; methanol;
DOI:10.1039/b604073j

Reference yield:

: C₂₂H₂₉NO₂

: 908290-75-5
(R)-3-(3'-phenylpropanoyl)-4-iso-propyl-6,6-dimethyl-(1,3)-oxazinan-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: H₂ / Pd(OH)2/C / methanol / 3800.26 Torr

2.1: CeCl₃ / tetrahydrofuran / 4 h / 20 °C

2.2: 57 percent / tetrahydrofuran; diethyl ether / 10 h

3.1: 36 percent / LiHMDS / tetrahydrofuran / 12 h / -78 - 20 °C

With cerium(III) chloride; hydrogen; lithium hexamethyldisilazane; palladium dihydroxide; In tetrahydrofuran; methanol;
DOI:10.1039/b604073j