((2R,4S,6R)-2-Phenyl-6-triisopropylsilanyloxymethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

Base Information

Chemical Name:((2R,4S,6R)-2-Phenyl-6-triisopropylsilanyloxymethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester
CAS No.:251641-48-2
Molecular Formula:C₂₆H₄₄O₅Si
Molecular Weight:464.718
Hs Code.:

Synonyms:((2R,4S,6R)-2-Phenyl-6-triisopropylsilanyloxymethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

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Chemical Property of ((2R,4S,6R)-2-Phenyl-6-triisopropylsilanyloxymethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

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Technology Process of ((2R,4S,6R)-2-Phenyl-6-triisopropylsilanyloxymethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

There total 3 articles about ((2R,4S,6R)-2-Phenyl-6-triisopropylsilanyloxymethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 112348-03-5
(R)-3-Hydroxy-4-triisopropylsilanyloxy-butyric acid ethyl ester

: 251641-48-2
((2R,4S,6R)-2-Phenyl-6-triisopropylsilanyloxymethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: LDA / tetrahydrofuran / -78 °C

1.2: 84 percent / tetrahydrofuran / -78 - 20 °C

2.1: Et₂BOMe; NaBH₄ / methanol; tetrahydrofuran

3.1: pyridinium p-toluenesulfonate / CH₂Cl₂ / Heating

With sodium tetrahydroborate; diethyl methoxy borane; pyridinium p-toluenesulfonate; lithium diisopropyl amide; In tetrahydrofuran; methanol; dichloromethane; 1.1: Metallation / 1.2: Condensation / 2.1: Reduction / 3.1: Cyclization;
DOI:10.1021/jo9910987

Reference yield:

: 251641-47-1
5-hydroxy-3-oxo-6-triisopropylsilanyloxy-hexanoic acid tert-butyl ester

: 251641-48-2
((2R,4S,6R)-2-Phenyl-6-triisopropylsilanyloxymethyl-[1,3]dioxan-4-yl)-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: Et₂BOMe; NaBH₄ / methanol; tetrahydrofuran

2: pyridinium p-toluenesulfonate / CH₂Cl₂ / Heating

With sodium tetrahydroborate; diethyl methoxy borane; pyridinium p-toluenesulfonate; In tetrahydrofuran; methanol; dichloromethane; 1: Reduction / 2: Cyclization;
DOI:10.1021/jo9910987