C₂₂H₃₂O₂Si

Base Information

• Chemical Name: C₂₂H₃₂O₂Si
• CAS No.: 1246949-46-1
• Molecular Formula: C₂₂H₃₂O₂Si
• Molecular Weight: 356.58
• Mol file: 1246949-46-1.mol

Synonyms:C₂₂H₃₂O₂Si

Chemical Property of C₂₂H₃₂O₂Si

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₂₂H₃₂O₂Si

There total 1 articles about C₂₂H₃₂O₂Si which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(S)-2,3-dimethyl-1,3-butanediol (73295-12-2) + tert-butylchlorodiphenylsilane (58479-61-1) → C22H32O2Si (1246949-46-1)

Guidance literature:

With 1H-imidazole; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1021/ol1019663

Reference yield: 90.0%

3,4-dihydro-2H-pyran (110-87-2) + C22H32O2Si (1246949-46-1) → C27H40O3Si (1246949-36-9)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; at 20 ℃; for 2.5h; Inert atmosphere;

DOI:10.1021/ol1019663

Reference yield:

C22H32O2Si (1246949-46-1) → C47H66O6 (1246949-28-9)

Guidance literature:

Multi-step reaction with 5 steps

1.1: pyridinium p-toluenesulfonate / dichloromethane / 2.5 h / 20 °C / Inert atmosphere

2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

3.1: tetrapropylammonium perruthennate; 4-methylmorpholine N-oxide / dichloromethane / 0 - 20 °C / Inert atmosphere; Molecular sieve

4.1: n-butyllithium / tetrahydrofuran; diethyl ether; hexane / 0.75 h / -78 °C / Inert atmosphere

4.2: 1.17 h / -78 - 0 °C / Inert atmosphere

5.1: n-butyllithium / tetrahydrofuran; hexane / 1 h / -78 °C / Inert atmosphere

5.2: 2 h / -78 °C / Inert atmosphere

With n-butyllithium; tetrapropylammonium perruthennate; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; 4-methylmorpholine N-oxide; In tetrahydrofuran; diethyl ether; hexane; dichloromethane;

DOI:10.1021/jo102054r

upstream raw materials:

(S)-2,3-dimethyl-1,3-butanediol

tert-butylchlorodiphenylsilane

Downstream raw materials:

C₂₇H₄₀O₃Si

C₄₇H₆₆O₆

(3α,5α,11β,17ξ,22S,24S)-3,11-bis(benzyloxy)-24-methyl-22,25-epoxyfurostan-20-ol