3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid

Base Information

Chemical Name:3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid
CAS No.:1208329-77-4
Molecular Formula:C₂₂H₂₂N₂O₄
Molecular Weight:378.428
Hs Code.:

Synonyms:3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid

There total 11 articles about 3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₆N₂O₄

: 1208329-77-4
3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid

Guidance literature:: With sodium hydroxide; In ethanol; at 20 ℃;
DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

: 1208330-62-4
C₂₀H₂₀N₂O₃

: 1208329-77-4
3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: manganese(IV) oxide / dichloromethane / 48 h / Reflux

2: toluene / Reflux

3: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr

4: sodium hydroxide / ethanol / 20 °C

With manganese(IV) oxide; palladium 10% on activated carbon; hydrogen; sodium hydroxide; In methanol; ethanol; dichloromethane; toluene; 2: Wittig reaction;
DOI:10.1016/j.bmcl.2011.04.086

Reference yield:

: ethyl 3-(4-bromo-2-methylphenyl)-3-oxopropanoate

: 1208329-77-4
3-(2-(4-carbamoyl-2-methylphenyl)-1-(4-methoxyphenyl)-1H-pyrrol-3-yl)propanoic acid

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.5 h / 0 °C / Inert atmosphere

1.2: Inert atmosphere; Reflux

2.1: ozone / dichloromethane / 1 h / -78 °C

3.1: pyridinium p-toluenesulfonate / ethanol / 20 °C

4.1: N,N-dimethyl-formamide / 12 h / 180 °C

5.1: diisobutylaluminium hydride / toluene / 2 h / -78 °C

6.1: manganese(IV) oxide / dichloromethane / 48 h / Reflux

7.1: toluene / Reflux

8.1: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 20 °C / 760.05 Torr

9.1: sodium hydroxide / ethanol / 20 °C

With manganese(IV) oxide; palladium 10% on activated carbon; hydrogen; pyridinium p-toluenesulfonate; sodium hydride; diisobutylaluminium hydride; ozone; sodium hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil; 7.1: Wittig reaction;
DOI:10.1016/j.bmcl.2011.04.086