2',4'-DIHYDROXY-3-(P-METHOXYPHENYL)-PROPIOPHENONE

Base Information

• Chemical Name: 2',4'-DIHYDROXY-3-(P-METHOXYPHENYL)-PROPIOPHENONE
• CAS No.: 93435-21-3
• Molecular Formula: C16H16 O4
• Molecular Weight: 272.301
• Hs Code.: 2914509090
• Mol file: 93435-21-3.mol

Synonyms:Propiophenone,2',4'-dihydroxy-3-(p-methoxyphenyl)- (7CI); 4-O-Methyl davidigenin

Chemical Property of 2',4'-DIHYDROXY-3-(P-METHOXYPHENYL)-PROPIOPHENONE

Chemical Property:

• Vapor Pressure: 2.79E-10mmHg at 25°C
• Refractive Index: 1.609
• Boiling Point: 491.4°Cat760mmHg
• Flash Point: 184.5°C
• PSA: 66.76000
• Density: 1.243g/cm³
• LogP: 2.92190

Purity/Quality:

98% ^*data from raw suppliers

2',4'-DIHYDROXY-3-(P-METHOXYPHENYL)-PROPIOPHENONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2',4'-DIHYDROXY-3-(P-METHOXYPHENYL)-PROPIOPHENONE

There total 11 articles about 2',4'-DIHYDROXY-3-(P-METHOXYPHENYL)-PROPIOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

3-(4-methoxyphenyl)propanoic acid (1929-29-9) + recorcinol (108-46-3) → 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)propane-1-one (93435-21-3)

Guidance literature:

With boron trifluoride diethyl etherate; at 80 - 90 ℃; for 1.5h;

DOI:10.1016/j.tet.2005.10.059

Reference yield:

1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)-prop-2-en-1-one (81674-91-1,13351-10-5) → 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)propane-1-one (93435-21-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h;

DOI:10.1021/jm300588j

Reference yield:

2',4'-dihydroxy-4-acetophenone (89-84-9) → 1-(2,4-dihydroxyphenyl)-3-(4-methoxyphenyl)propane-1-one (93435-21-3)

Guidance literature:

Multi-step reaction with 2 steps

1: KOH / ethanol / 20 °C

2: H₂ / Pd/C

With potassium hydroxide; hydrogen; palladium on activated charcoal; In ethanol; 1: Claisen-Schmidt condensation;

DOI:10.1016/j.bmcl.2004.05.071

upstream raw materials:

(E)-1-(4-(benzyloxy)-2-hydroxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-one

recorcinol

3-(4-methoxyphenyl)propanoic acid

2',4'-dihydroxy-4-acetophenone

Downstream raw materials:

crotaramin

3-(4-methoxybenzyl)-4-oxo-4H-chromen-7-yl (9Z)-oleate

3-(4-methoxybenzyl)-4-oxo-4H-chromen-7-yl (10E,12Z)-linoleate

3-(4-methoxybenzyl)-4-oxo-4H-chromen-7-yl stearate

Refernces

• 1、 Gan, Li-She,Zeng, Lin-Wei,Li, Xiang-Rong,Zhou, Chang-Xin,Li, Jie. "New homoisoflavonoid analogues protect cells by regulating autophagy". . p. 1441 - 1445. Retrieved 2017/03/08.
• 2、 Zhao, Wei,Sun, Jie,Xiang, Hua,Zeng, Yan-Yan,Li, Xiao-Bo,Xiao, Hong,Chen, De-Ying,Ma, Ren-Ling. "Synthesis and biological evaluation of new flavonoid fatty acid esters with anti-adipogenic and enhancing glucose consumption activities". experimental part. p. 3192 - 3203. Retrieved 2011/06/24.